ArticleJournal of affective disorders2022
Associated functional network connectivity between callous-unemotionality and cognitive and affective empathy.
Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- A comprehensive systematic review of fMRI studies on brain connectivity in healthy children and adolescents: Current insights and future directions.Developmental cognitive neuroscience · 2024Pooled it
- Affective theory of mind impairments linked with callous-unemotional traits implicate cognitive control: A pre-registered double-blind randomized controlled trial with a dual-task paradigm.Journal of affective disorders · 2025Trial
- White matter microstructure of the cingulum bundle and the uncinate fasciculus in primary and secondary callous-unemotional traits.European child & adolescent psychiatry · 2025Article
- Latent Default Mode Network Connectivity Patterns: Associations With Sleep Health and Adolescent Psychopathology.Brain and behavior · 2025Article
- Cognitive and affective perspective taking amongst adolescent offenders with variants of callous-unemotional traits.European child & adolescent psychiatry · 2024Article
- Newborn Brain Function and Early Emerging Callous-Unemotional Traits.JAMA psychiatry · 2024Article
- Executive function and underlying brain network distinctions for callous-unemotional traits and conduct problems in adolescents.bioRxiv : the preprint server for biology · 2023Article
- Efficiency of Heterogenous Functional Connectomes Explains Variance in Callous-Unemotional Traits After Computational Lesioning of Cortical Midline and Salience Regions.Brain connectivity · 2023Article
- Connectome-based predictive modeling of empathy in adolescents with and without the low-prosocial emotion specifier.Neuroscience letters · 2023Article
- Resting-state connectivity underlying cognitive control's association with perspective taking in callous-unemotional traits.Psychiatry research. Neuroimaging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLow empathy is one component of affective impairments defining the antisocial youth phenotype callous-unemotional (CU) traits. Research suggests CU traits may be negatively associated with neural networks that are positively associated with cognitive and affective empathy - specifically the default mode (DMN), frontoparietal (FPN), and salience (SAL) networks. Determining which functional network connections are shared between CU traits and empathy could elucidate the extent to which CU traits shares neural substrates with cognitive versus affective empathy. The present study tested whether CU traits and both cognitive and affective empathy share network connections within and between the DMN, FPN, and SAL.
methodsParticipants (n = 112, aged 13-17, 43 % female) completed resting-state functional magnetic resonance imaging and self-reports for CU traits and empathy as part of a Nathan-Kline Institute study.
resultsAnalyses revealed inverse associations with shared network connections between CU traits and both cognitive and affective empathy. Specifically, within-DMN connectivity negatively associated with CU traits, but positively associated with cognitive empathy; and between DMN-SAL connectivity positively associated with CU traits, but negatively associated with both cognitive and affective empathy. However, joint models revealed little variance explained by CU traits and empathy overlapped. LIMITATIONS: The sample was cross-sectional collection with limited participants (n = 112) from the community that may not generalize to incarcerated adolescents.
conclusionsResults demonstrate CU traits inversely associated with similar connectivity patterns as cognitive and affective empathy though prediction among constructs did not significantly overlap. Further investigation of these connections can inform a mechanistic understanding of empathy impairments in CU traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.