Evidence map›Paper›PMID 36063964›Full record

ArticleExperimental eye research2022

Roles of CCL2 and CCL3 in intraocular inflammation during Bacillus endophthalmitis.

Md Huzzatul Mursalin, Roger Astley, Phillip S Coburn, Frederick C Miller, Michelle C Callegan

Open access · greenAbstract read
In one paragraph

Article in Experimental eye research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026
    Review
  2. Infection and immunity · 2026
    Article
  3. Article
  4. Article
  5. Article
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  10. Virulence-related genotypic differences amongFrontiers in cellular and infection microbiology · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Md Huzzatul MursalinDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Roger AstleyDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Dean McGee Eye Institute, Oklahoma City, OK, USA.
Phillip S CoburnDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Dean McGee Eye Institute, Oklahoma City, OK, USA.
Frederick C MillerDepartment of Cell Biology and Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Michelle C CalleganDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Dean McGee Eye Institute, Oklahoma City, OK, USA; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: http://calleganlab.org.
University of Oklahoma Health Sciences Center · US

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan · 2011 to 2026
$10.5M
Pathogenic Mechanisms of Bacillus EndophthalmitisR01EY028810 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2018 to 2022
$1.8M
Semantic Guidance of Visual AttentionR01EY021802 · NEI · UNIVERSITY OF MASSACHUSETTS BOSTON · PI POMPLUN, MARC · 2012 to 2014
$653k
Targeting Chemokines in Intraocular InfectionR21EY028066 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2019 to 2020
$399k
Phage-Based Therapeutics for Ocular InfectionsR21EY031802 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2020 to 2021
$392k
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY021802NEI NIH HHS R01 EY028810NEI NIH HHS R21 EY028066NEI NIH HHS R21 EY031802
6 · The paper itself

Abstract

Bacillus cereus (B. cereus) endophthalmitis is a vision-threatening bacterial infection. Uncontrolled inflammatory responses are the hallmark of this disease which cause irreversible damage to the retina. We recently reported C-X-C chemokines as a vital modulators which impacted the pathogenesis of this disease. Here, we investigated the impact of two highly upregulated C-C chemokines, CCL2 and CCL3, on intraocular inflammation this disease. B. cereus was injected into the eyes of C57BL/6J (WT), CCL2

Indexed as

BacillusChemokine CCL2EndophthalmitisEye Infections, BacterialUveitisAnimalsAnti-Bacterial AgentsBacillus cereusChemokine CCL3ElectroretinographyGatifloxacinInflammationMiceMice, Inbred C57BLAnti-Bacterial AgentsCcl2 protein, mouseCcl3 protein, mouseChemokine CCL2Chemokine CCL3GatifloxacinBacillus cereusChemokineEndophthalmitisImmune responsesInflammationOcular infection

Identifiers

PMID36063964
PMCPMC9826602
OpenAlexW4294190130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.