ArticleThe American journal of medicine2022
Activities of Daily Living and Outcomes in Patients with Advanced Heart Failure.
Article in The American journal of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Clinical Impact of Hospital-Associated Disability in Patients With Acute Decompensated Heart Failure.Circulation reports · 2026Article
- Examining the Association Between Occupational Strain and Risk of Angina Pectoris Among Older Working Adults in India Using Karasek's Job Demand Control Model.Research square · 2026Article
- Development and Interpretation of Machine Learning Models for Short-Term Functional Recovery and 90-Day Readmission in Patients with Cardiovascular Disease.Journal of multidisciplinary healthcare · 2026Article
- Development and Validation of a Prognostic Model for One-year Mortality in Older Adults with Acute Myocardial Infarction Incorporating Activities of Daily Living Impairment.Clinical interventions in aging · 2026Article
- Using Latent Class Analysis to Identify Different Clinical Profiles Among Patients With Advanced Heart Failure.Journal of pain and symptom management · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFunctional debility is associated with worse outcomes in the general heart failure population, but the prevalence of difficulty with activities of daily living and clinical significance once patients develop advanced heart failure requires further examination.
methodsThis was a population-based, retrospective cohort study of Olmsted County, Minnesota adults with advanced heart failure from 2007-2018. Difficulty with 9 activities of daily living was assessed by questionnaire. Predictors of difficulty were assessed by a proportional odds model. Associations of difficulty with activities of daily living with mortality and hospitalization were examined using Cox and Andersen-Gill models.
resultsAmong 765 patients with advanced heart failure, 565 (73.9%) reported difficulty with activities of daily living at diagnosis. Of those, 257 (45%) had moderate and 148 (26%) had severe difficulty. Independent predictors of difficulty included female sex (odds ratio [OR] 1.73; 95% confidence interval [CI], 1.26-2.36; P = .001), older age (OR per 10-year increase 1.17; 95% CI, 1.05-1.31; P = .005), dementia (OR 1.85; 95% CI, 1.06-3.24; P = .031), depression (OR 1.75; 95% CI, 1.28-2.40; P = .001), and morbid obesity (OR 1.49; 95% CI, 1.04-2.13; P = .031). Estimated 2-year mortality was 61.5%, 64.2%, and 67.6% in patients with no/minimal, moderate, and severe difficulty, respectively. The adjusted hazard ratios (95% CI) for death were 1.08 (0.90-1.28) and 1.17 (0.95-1.43) for moderate and severe difficulty, respectively, vs no/minimal difficulty (P = .33). There were no statistically significant associations of difficulty with activities of daily living and hospitalization risks.
conclusionsMost patients with advanced heart failure have difficulty completing activities of daily living and are at high risk of mortality regardless of impairment in activities of daily living.
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