ArticleEuropean journal of dentistry2023
Active MMP-8 as a Biomarker of Peri-implant Health or Disease.
Article in European journal of dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Comparison of Chlorhexidine, Chlorhexidine with anti-discoloration system, and Polyvinylpyrrolidone-iodine on early wound healing after dental implant placement: A randomized clinical trial.Clinical oral investigations · 2025Trial
- Oral Mucositis in Oncopediatric Patients: MTX and MMP-1, MMP-8, MMP-13 Gene Polymorphisms.Oral diseases · 2026Article
- Biomarker-Guided Implant Maintenance (BGIM): A Narrative Review and Protocol Proposal.Journal of clinical medicine · 2026Review
- Influence of Obesity on Peri-Implant Health: A Cross-Sectional Clinical and Biochemical Study.Diagnostics (Basel, Switzerland) · 2026Article
- Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap.Bioactive materials · 2025Review
- Diagnostic Accuracy of Active MMP-8 Point-of-Care Test in Peri-Implantitis.European journal of dentistry · 2025Article
- Comparison of clinical parameters of peri-implantitis and parameters related to tissue macrophage sensitization on TiOClinical oral investigations · 2024Article
- Diagnostic value of aMMP-8 and azurocidin in peri-implant sulcular fluid as biomarkers of peri-implant health or disease.Clinical and experimental dental research · 2024Article
- Clinical parameters and inflammatory biomarkers among patients with multibracket appliances: a prospective clinical trial.BMC oral health · 2024Article
- Peri-implant diseases diagnosis, prognosis and dental implant monitoring: a narrative review of novel strategies and clinical impact.BMC oral health · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study investigated the potential of testing for active matrix metalloproteinase-8 (aMMP-8) by a quantitative point-of-care (PoC), chairside, lateral flow immunotest as a biomarker for the presence or absence of peri-implant diseases. MATERIALS AND
methodsEighty healthy patients with implants were recruited. The samples were collected from peri-implant sulcular fluid and quantitatively analyzed for aMMP-8. Clinical indices, which included probing depth, clinical attachment loss, bleeding on probing, and plaque, were recorded and radiographic assessments were performed. STATISTICAL ANALYSIS: Comparisons of aMMP-8 levels and clinical parameters were analyzed by the Kruskal-Wallis test and the pairwise post hoc Dunn-Bonferroni test. A receiver operating curve analysis was used to analyze the diagnostic ability of aMMP-8 and the correlation between aMMP-8 and probing depth of the sampled site was sought by Spearman's rho and the coefficient of determination (
resultsStatistical analysis revealed statistically significant differences of aMMP-8 levels between the healthy and the mucositis and peri-implantitis groups, and between the mucositis and the peri-implantitis groups. Increasing probing depths of the sampled site and aMMP-8 levels were significantly correlated.
conclusionsThese data suggest that the aMMP-8 PoC test can be a beneficial adjunctive tool for early identification and screening of the risk of peri-implant diseases and progression.
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Registered trials
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