ArticleVeterinary medicine and science2022
Saffron extract feed improves the antioxidant status of laying hens and the inhibitory effect on cancer cells (PC3 and MCF7) Growth.
Article in Veterinary medicine and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Efficacy of Saffron (Integrative cancer therapiesPooled it
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- Functional Feed for Laying Hens: Application of Saffron Extract as Eco-Friendly Supplement With Cholesterol-Lowering Properties.Veterinary medicine and science · 2025Article
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- Use of black pepper oil in growing-quail diets and its impact on growth, carcass measurements, intestinal microbiota, and blood chemistry.Archives animal breeding · 2024Article
- Yolk Fatty Acid Content, Lipid Health Indices, and Oxidative Stability in Eggs of Slow-Growing Sasso Chickens Fed on Flaxseed Supplemented with Plant Polyphenol Extracts.Foods (Basel, Switzerland) · 2023Article
- The Role of Supplementing a Complex Phytobiotic Feed Additive Containing (Veterinary sciences · 2023Article
- Impact of Supplementing Phytobiotics as a Substitute for Antibiotics in Broiler Chicken Feed on Growth Performance, Nutrient Digestibility, and Biochemical Parameters.Veterinary sciences · 2022Article
- Saffron extract feed improves the antioxidant status of laying hens and the inhibitory effect on cancer cells (PC3 and MCF7) Growth.Veterinary medicine and science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere have been some reports regarding supplementation of saffron petal extract on performance and egg quality in laying hens. However, the effect of saffron petal extract fed diet at different amounts on antioxidant status of laying hens and the impact of the resulting egg yolk on growth/inhibitory activity of cancer cells has not been fully studied.
objectivesThe effect of dried saffron petal extract on the laying performance, egg qualitative traits, antioxidant status, and its inhibitory effect on cancer cells was studied.
methodsA total of 200 39-week-old Hy-line W36 Leghorn laying hens were selected based on a completely randomised design in four treatments with five replications (10 hens per replication). The four treatment diets consisted of a basal diet with no supplement (control), and three diet supplement groups containing 40, 60 and 80 ppm of saffron petal extract.
resultsAdding 80 ppm of saffron petal extract to layer diets increased egg production (p < 0.05). Malondialdehyde,1,1-diphenyl-2-picrylhydrazyl value and Superoxide dismutase significantly improved by saffron petal dietary supplementation. The yolk weight and colour, Haugh unit and shell weight and thickness were also influenced (p < 0.05) with highest values achieved in the 60 ppm saffron extract supplemented diet. Results demonstrated a significant effect of saffron extract inclusion in the diet on the growth of Michigan Cancer Foundation-7 and Prostate Cancer Cell in a positive dose-dependent manner (p < 0.05) and the most intense inhibitory effect on cancer cells was observed with 60-80 ppm extract.
conclusionsSaffron petal extract can be used to potentially modulate the antioxidant status of laying hens and the inhibitory effect on cancer cells, best achieved with 60-80 ppm extract.
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