Evidence map›Paper›PMID 36063502›Full record

ArticleMagnetic resonance in medicine2023

Guanidinium and amide CEST mapping of human brain by high spectral resolution CEST at 3 T.

Kexin Wang, Sooyeon Park, David Olayinka Kamson, Yuguo Li, Guanshu Liu, Jiadi Xu

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  13. Creatine mapping of the brain at 3T by CEST MRI.Magnetic resonance in medicine · 2024
    Article
  14. The exchange rate of creatine CEST in mouse brain.Magnetic resonance in medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kexin WangF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.ORCID 0000-0003-0124-0631
Sooyeon ParkF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
David Olayinka KamsonThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.
Yuguo LiF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
Guanshu LiuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.ORCID 0000-0002-8188-4332
Jiadi XuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.ORCID 0000-0001-9698-5622
Kennedy Krieger Institute · USJohns Hopkins University · US

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
MRI based phosphocreatine mapping method to assess patients with peripheral arterial disease.R01HL149742 · NHLBI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Michael Schaer, JIadi Xu · 2020 to 2026
$2.5M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
Altered pH in early Alzheimer's disease detected by creatine chemical exchange saturation transfer MRIR21AG074978 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, JIADI · 2022 to 2022
$444k
NHLBI NIH HHS R01 HL149742NIA NIH HHS R21 AG074978NIBIB NIH HHS P41 EB031771NIH HHS S10 OD021648
6 · The paper itself

Abstract

purposeTo extract guanidinium (Guan) and amide CEST on the human brain at 3 T MRI with the high spectral resolution (HSR) CEST combined with the polynomial Lorentzian line-shape fitting (PLOF).

methodsContinuous wave (cw) turbo spin-echo (TSE) CEST was implemented to obtain the optimum saturation parameters. Both Guan and amide CEST peaks were extracted and quantified using the PLOF method. The NMR spectra on the egg white phantoms were acquired to reveal the fitting range and the contributions to the amide and GuanCEST. Two types of CEST approaches, including cw gradient- and spin-echo (cwGRASE) and steady state EPI (ssEPI), were implemented to acquire multi-slice HSR-CEST.

resultsGuanCEST can be extracted with the PLOF method at 3 T, and the optimum

conclusionGuan and amide CEST mapping can be achieved by the HSR-CEST at 3 T combing with the PLOF method.

Indexed as

AmidesBrainGray MatterGuanidineHumansMagnetic Resonance ImagingAmidesGuanidineamide CESTchemical exchange saturation transfer (CEST)continuous wave gradient- and spin-echo  (cwGRASE)guanidinium CESTmagnetization transfer contrast (MTC)polynomial Lorentzian line-shape fitting (PLOF)steady state EPI (ssEPI)

Identifiers

PMID36063502
PMCPMC9617768
OpenAlexW4294643601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.