Evidence map›Paper›PMID 36063499›Full record

ArticleMagnetic resonance in medicine2023

Deuterium metabolic imaging of the human brain in vivo at 7 T.

Eulalia Serés Roig, Henk M De Feyter, Terence W Nixon, Loreen Ruhm, Anton V Nikulin, Klaus Scheffler, Nikolai I Avdievich, Anke Henning, Robin A de Graaf

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Review
  5. Assessment of TMagma (New York, N.Y.) · 2026
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  9. Observational
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  15. Article
  16. Article
  17. Human Brain Deuterium Metabolic Imaging at 7 T: Impact of Different [6,6'-Journal of magnetic resonance imaging : JMRI · 2025
    Article
  18. Article
  19. Development of a Double TunedNMR in biomedicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eulalia Serés RoigDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-6524-3826
Henk M De FeyterDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-6111-0316
Terence W NixonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.
Loreen RuhmHigh-Field MR Centre, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID 0000-0001-7217-2993
Anton V NikulinHigh-Field MR Centre, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Klaus SchefflerHigh-Field MR Centre, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID 0000-0001-6316-8773
Nikolai I AvdievichHigh-Field MR Centre, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID 0000-0001-7608-0869
Anke HenningHigh-Field MR Centre, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Robin A de GraafDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-6570-7010

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Deuterium metabolic imaging (DMI) of neurological diseaseR01EB025840 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2019 to 2026
$4.2M
NCATS NIH HHS UL1 TR001863NIBIB NIH HHS R01 EB025840
6 · The paper itself

Abstract

purposeTo explore the potential of deuterium metabolic imaging (DMI) in the human brain in vivo at 7 T, using a multi-element deuterium (

methods

results3D DMI maps covering the entire human brain in vivo were obtained from well-resolved deuterated (

conclusionHere, we have demonstrated the successful implementation of 3D DMI in the human brain in vivo at 7 T. The spatial and temporal nominal resolutions achieved at 7 T (i.e., 2.7 mL in 28 min, respectively) were close to those achieved at 9.4 T and greatly outperformed DMI at lower magnetic fields. DMI at 7 T and beyond has clear potential in applications dealing with small brain lesions.

Indexed as

BrainImaging, Three-DimensionalDeuteriumGlucoseHumansMagnetic Resonance ImagingWaterDeuteriumGlucoseWater7 Tesla (7 T)brain energy metabolismdeuterium (2H)deuterium metabolic imaging (DMI)glucoseglutamate/glutamine (Glx)human brainwater

Identifiers

PMID36063499
PMCPMC9756916

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.