Evidence map›Paper›PMID 36063172›Full record

ArticleCancer immunology, immunotherapy : CII2023

Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities.

Zhen Lu, Eun-Ah Bae, Ioannis I Verginadis, Hongru Zhang, Christina Cho, Noreen McBrearty, Subin S George, J Alan Diehl, Constantinos Koumenis, Linda M Bradley and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. T cell-intrinsic integrated stress response: friend, foe, or frill?Journal of the National Cancer Center · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zhen LuDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 380 S. University Ave, Hill 316, Philadelphia, PA, 19104, USA.
Eun-Ah BaeAging, Cancer, and Immuno-Oncology Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Ioannis I VerginadisDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hongru ZhangDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 380 S. University Ave, Hill 316, Philadelphia, PA, 19104, USA.
Christina ChoDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 380 S. University Ave, Hill 316, Philadelphia, PA, 19104, USA.
Noreen McBreartyDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 380 S. University Ave, Hill 316, Philadelphia, PA, 19104, USA.
Subin S GeorgeInstitute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
J Alan DiehlDepartment of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Constantinos KoumenisDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Linda M BradleyAging, Cancer, and Immuno-Oncology Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Serge Y FuchsDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 380 S. University Ave, Hill 316, Philadelphia, PA, 19104, USA. syfuchs@vet.upenn.edu.
University of Pennsylvania · USSanford Burnham Prebys Medical Discovery Institute · USUniversity School · US

Funding

UPR, interferon signaling and tumorigenesisP01CA165997 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DIEHL, JOHN ALAN · 2013 to 2023
$10.9M
Training In Tumor VirologyT32CA115299 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2006 to 2021
$4.7M
Linking the microbiome and immune-checkpoint in melanoma by RNF5R01CA216187 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI BRADLEY, LINDA MAC PHERSON · 2017 to 2021
$3.0M
Type I Interferon Pathway in Pancreatic AdenocarcinomaR01CA240814 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FUCHS, SERGE Y · 2020 to 2024
$1.8M
NCI NIH HHS CA115299NCI NIH HHS CA165997NCI NIH HHS CA216187NCI NIH HHS CA240814NCI NIH HHS P01 CA165997NCI NIH HHS R01 CA216187NCI NIH HHS R01 CA240814NCI NIH HHS T32 CA115299
6 · The paper itself

Abstract

Immune suppressive factors of the tumor microenvironment (TME) undermine viability and exhaust the activities of the intratumoral cytotoxic CD8 + T lymphocytes (CTL) thereby evading anti-tumor immunity and decreasing the benefits of immune therapies. To counteract this suppression and improve the efficacy of therapeutic regimens, it is important to identify and understand the critical regulators within CD8 + T cells that respond to TME stress and tumor-derived factors. Here we investigated the regulation and importance of activating transcription factor-4 (ATF4) in CTL using a novel Atf4

Indexed as

Lymphocytes, Tumor-InfiltratingNeoplasmsActivating Transcription FactorsAnimalsCD8-Positive T-LymphocytesMiceT-Lymphocytes, CytotoxicTumor MicroenvironmentActivating Transcription FactorsAntigen activationAnti-tumor immunityATF4CD8 + T cellsCytotoxic T lymphocytesTumor microenvironment and stress

Identifiers

PMID36063172
PMCPMC10317204
OpenAlexW4294612958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.