Evidence map›Paper›PMID 36063033›Full record

ArticleNanoscale2022

Combining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid carriers during blood-brain barrier crossing.

Matteo Battaglini, Natalia Feiner, Christos Tapeinos, Daniele De Pasquale, Carlotta Pucci, Attilio Marino, Martina Bartolucci, Andrea Petretto, Lorenzo Albertazzi, Gianni Ciofani

Open access · hybridAbstract read
In one paragraph

Article in Nanoscale, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Matteo BattagliniIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. matteo.battaglini@iit.it.ORCID http://orcid.org/0000-0003-3601-1425
Natalia FeinerEindhoven University of Technology Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), PO Box 513, 5612AZ Eindhoven, The Netherlands.
Christos TapeinosIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. matteo.battaglini@iit.it.ORCID http://orcid.org/0000-0001-8192-6750
Daniele De PasqualeIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. matteo.battaglini@iit.it.
Carlotta PucciIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. matteo.battaglini@iit.it.ORCID http://orcid.org/0000-0002-8976-3711
Attilio MarinoIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. matteo.battaglini@iit.it.ORCID http://orcid.org/0000-0002-3290-494X
Martina BartolucciIRCCS Istituto Giannina Gaslini, Core Facilities-Clinical Proteomics and Metabolomics, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Andrea PetrettoIRCCS Istituto Giannina Gaslini, Core Facilities-Clinical Proteomics and Metabolomics, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Lorenzo AlbertazziEindhoven University of Technology Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS), PO Box 513, 5612AZ Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0002-6837-0812
Gianni CiofaniIstituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera (Pisa), Italy. matteo.battaglini@iit.it.ORCID http://orcid.org/0000-0003-1192-3647
Piaggio (Italy) · ITInstitute for Bioengineering of Catalonia · ESIstituto Giannina Gaslini · IT

Funding

European Research Council 709613
6 · The paper itself

Abstract

Upon coming into contact with the biological environment, nanostructures are immediately covered by biomolecules, particularly by proteins forming the so-called "protein corona" (PC). The phenomenon of PC formation has gained great attention in recent years due to its implication in the use of nanostructures in biomedicine. In fact, it has been shown that the formation of the PC can impact the performance of nanostructures by reducing their stability, causing aggregation, increasing their toxicity, and providing unexpected and undesired nanostructure-cell interactions. In this work, we decided to study for the first time the formation and the evolution of PC on the surface of nanostructured lipid carriers loaded with superparamagnetic iron oxide nanoparticles, before and after the crossing of an

Indexed as

NanoparticlesNanostructuresProtein CoronaBlood-Brain BarrierEndothelial CellsLipidsMass SpectrometryMicroscopy, ConfocalProteomicsSerum Albumin, BovineLipidsProtein CoronaSerum Albumin, Bovine

Identifiers

PMID36063033
PMCPMC9494355
OpenAlexW4290996919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.