Evidence map›Paper›PMID 36062815›Full record

Observational studyAnnals of medicine2022

The role of prognostic stratification on prescription of anticoagulants in older patients with atrial fibrillation: a multicenter, observational, prospective European study (EUROSAF).

Alberto Pilotto, Nicola Veronese, Maria Cristina Polidori, Timo Strandberg, Eva Topinkova, Alfonso J Cruz-Jentoft, Carlo Custodero, Stefania Maggi, EUROSAF Study Investigators

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 8 countries.

Alberto PilottoGeriatrics Unit, Department of Geriatric Care, OrthoGeriatrics and Rehabilitation, E.O. Galliera Hospital, Genova, Italy.
Nicola VeroneseGeriatrics Unit, Department of Internal Medicine, University of Palermo, Palermo, Italy.ORCID 0000-0002-9328-289X
Maria Cristina PolidoriAgeing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Timo StrandbergUniversity of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-6299-925X
Eva TopinkovaFirst Faculty of Medicine, Charles University in Prague, Czech Republic.
Alfonso J Cruz-JentoftServicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.
Carlo CustoderoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Stefania MaggiNational Research Council, Neuroscience Section, Padova, Italy.
EUROSAF Study Investigators
Charles University · CZEnte Ospedaliero Ospedali Galliera · ITInstituto Ramón y Cajal de Investigación Sanitaria · ESNational Research Council · ROUniversity of Bari Aldo Moro · ITUniversity of Cologne · DEUniversity of Helsinki · FIUniversity of Palermo · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiterature suggests that different risks of mortality could influence physicians in prescribing or not anticoagulants in older patients with atrial fibrillation (AF). The Multidimensional Prognostic Index (MPI) can be considered a tool for the detection of multidimensional frailty. The aim of this cross-sectional study was to evaluate whether prescription patterns of oral anticoagulants exist, based on MPI values.

methodsOlder hospitalised patients (age ≥ 65 years) with non-valvular AF were included across 24 European centres. MPI was calculated using validated and standardised tools derived from a comprehensive geriatric assessment. Other functional and clinical information were collected to calculate indexes specific for haemorrhagic and thromboembolic risk in AF.

resultsAltogether, 2,012 participants affected by AF (mean age was 83.2 ± 7.5, range: 65-104 years), with a higher presence of women (57.0%), were included. Overall, 440 took vitamin K antagonists VKAs (22.0%), 667 (33.4%) direct oral anticoagulants (DOACs), whilst 44.6% did not take any anticoagulant treatment. Prescription of anticoagulants was associated with MPI values, with people taking anticoagulants having lower mean MPI values. Anticoagulant therapy was not used in 53.1% of the group with the highest risk of mortality, compared with 32.3% of those in the group with the lowest mortality risk. People with higher scores in MPI were less frequently treated with anticoagulant therapy, after adjusting for several potential confounders.

conclusionsThe EURopean study of Older Subjects with Atrial Fibrillation (EUROSAF) suggested that almost half of the older persons with AF do not receive anticoagulants and that MPI is an important determinant in prescribing or not anticoagulants.

Indexed as

Atrial FibrillationStrokeAdministration, OralAgedAged, 80 and overAnticoagulantsCross-Sectional StudiesFemaleHumansPrescriptionsPrognosisProspective StudiesRisk FactorsAnticoagulantsanticoagulantscomprehensive geriatric assessmentEUROSAFfrailtymultidimensional prognostic indexolder people

Identifiers

PMID36062815
PMCPMC9448408
OpenAlexW4294666623

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.