Evidence map›Paper›PMID 36062490›Full record

ArticleDrug delivery2022

Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment:

Ayca Yildiz Pekoz, Ozlem Akbal Dagistan, Hanan Fael, Meltem Culha, Aybige Erturk, Nur Sena Basarir, Gokben Sahin, Muge Serhatli, Gamze Cakirca, Saban Tekin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ayca Yildiz PekozFaculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, Istanbul, Türkiye.
Ozlem Akbal DagistanFaculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, Istanbul, Türkiye.
Hanan FaelFaculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, Istanbul, Türkiye.
Meltem CulhaFaculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, Istanbul, Türkiye.
Aybige ErturkFaculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, Istanbul, Türkiye.
Nur Sena BasarirFaculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, Istanbul, Türkiye.
Gokben SahinFaculty of Pharmacy, Department of Pharmaceutical Technology, Trakya University, Istanbul, Türkiye.
Muge SerhatliMedical Biotechnology (Marmara Research Center (MRC)), TUBITAK Marmara Research Center-MRC, Life Sciences, Kocaeli, Türkiye.
Gamze CakircaMedical Biotechnology (Marmara Research Center (MRC)), TUBITAK Marmara Research Center-MRC, Life Sciences, Kocaeli, Türkiye.
Saban TekinMedical Biotechnology (Marmara Research Center (MRC)), TUBITAK Marmara Research Center-MRC, Life Sciences, Kocaeli, Türkiye.
Leyla Semiha SenSchool of Medicine, Basic Medical Sciences, Department of Physiology, Marmara University, Istanbul, Türkiye.
Mustafa SevimSchool of Medicine, Basic Medical Sciences, Department of Physiology, Marmara University, Istanbul, Türkiye.
Lutfiye Mulazimoglu DurmusogluSchool of Medicine, Department of Infectious Diseases, Marmara University, Istanbul, Türkiye.
Berrak C YegenSchool of Medicine, Basic Medical Sciences, Department of Physiology, Marmara University, Istanbul, Türkiye.
Istanbul University · TRMarmara University · TRTÜBİTAK Marmara Research Center · TRTrakya University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Favipiravir, an RNA-dependent RNA polymerase (RdRp) inhibitor, is used to treat patients infected with influenza virus and most recently with SARS-CoV-2. However, poor accumulation of favipiravir in lung tissue following oral administration has required an alternative method of administration that directly targets the lungs. In this study, an inhalation solution of favipiravir at a concentration of 2 mg mL

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentAmidesHumansLungPyrazinesRespiratory Aerosols and DropletsSARS-CoV-2AmidesAntiviral AgentsfavipiravirPyrazinesantiviral activityCOVID-19Favipiravirinhaled formulationrespiratory

Identifiers

PMID36062490
PMCPMC9448368
OpenAlexW4294631505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.