Evidence map›Paper›PMID 36062404›Full record

ArticleActa psychiatrica Scandinavica2023

Mortality and care of eating disorders.

Giovanni Castellini, Saverio Caini, Emanuele Cassioli, Eleonora Rossi, Giorgia Marchesoni, Francesco Rotella, Nora De Bonfioli Cavalcabo', Miriam Fontana, Barbara Mezzani, Brunetto Alterini and 2 more

Abstract read
In one paragraph

Article in Acta psychiatrica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut-Brain Axis via Ghrelin.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Leptin Levels in Acute and Recovered Eating Disorders: An Arm-Based Network Meta-Analysis.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Mortality and care of eating disorders.Acta psychiatrica Scandinavica · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Giovanni CastelliniPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Saverio CainiCancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Emanuele CassioliPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0003-3623-7096
Eleonora RossiPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0003-4755-3879
Giorgia MarchesoniPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Francesco RotellaPsychiatry Unit, Careggi University Hospital, Florence, Italy.
Nora De Bonfioli Cavalcabo'Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Miriam FontanaClinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Barbara MezzaniCasa di cura "Villa dei Pini", Florence, Italy.
Brunetto AlteriniDivision of Cardiovascular and Perioperative Medicine, Careggi University Hospital, Florence, Italy.
Stefano LucarelliUFS Eating Disorders ASL Toscana Centro, Florence, Italy.
Valdo RiccaPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEating disorders (EDs) are considered serious mental illnesses, with one of the highest lethality among psychiatric disorders, even though the issue of mortality due to these conditions is still controversial. The present study was aimed at comparing the mortality rate in a cohort of ED patients representative of the geographic area with that of the age and gender-matched general population of central Italy.

methodsPatients were enrolled between 1994 and 2018, among those attending the eating disorders treatment network of the Florence area (EDTN), which is a regional multidisciplinary treatment reference center for EDs covering the clinical population of the metropolitan Florence area (Italy). The life status of participants was determined through linkage with the Regional Mortality Registry.

resultsA total of 1277 individuals with EDs were included, including 368 with Anorexia Nervosa (AN), 312 with Bulimia Nervosa (BN), and 597 individuals with Binge Eating Disorder (BED). Twenty-two patients (1.72%) died, during a median follow-up of 7.4 years. The mortality rates among ED patients did not significantly differ from that of the general population of the same age and sex with a Standardized Mortality Ratio (SMR) of 1.19, 95% CI 0.79-1.81. Only among BN patients, the mortality was significantly increased after 10 years from clinical evaluation (SMR 11.24, 95% CI 3.62-34.84).

conclusionThe low mortality in EDs, compared to published studies, might be due to the EDTN treatment strategy, based on a large network which makes an integrated multidisciplinary team available for almost all the patients with EDs of the geographical area.

Indexed as

Anorexia NervosaBinge-Eating DisorderBulimia NervosaFeeding and Eating DisordersHumansItalyanorexia nervosabinge eating disorderbulimia nervosaeating disordersstandardized mortality ratio

Identifiers

PMID36062404
PMCPMC10086824

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.