Observational studyEuropean journal of physical and rehabilitation medicine2022
Aging after stroke: how to define post-stroke sarcopenia and what are its risk factors?
Observational study in European journal of physical and rehabilitation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06255145 (Assessment of Body Composition, Fatigue, Mobility and Functional Status in Post-Stroke Individuals), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Body Composition, Fatigue, Mobility and Functional Status in Post-Stroke Individuals
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Prevalence of Stroke-Related Sarcopenia: A Systematic Review and Meta-Analysis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Pooled it
- Risk factors of stroke-related sarcopenia: a systematic review and meta-analysis.Frontiers in aging · 2025Pooled it
- Effects of exercise intervention on physical mobility in stroke patients: a scoping review and research progress.Frontiers in neurology · 2025Pooled it
- Prevalence and associated factors of sarcopenia in stroke inpatients: a cross-sectional study with SarQoL-assessed quality of life.BMC neurology · 2026Article
- Post-stroke sarcopenia as a neuromuscular disorder: a mini review of neural mechanisms and clinical implications.Frontiers in neurology · 2026Review
- Associated factors for stroke-related sarcopenia: a scoping review.Frontiers in neurology · 2026Article
- The mediating role of activities of daily living in the association between nutritional risk and cognitive function among stroke survivors: a cross-sectional study.Frontiers in medicine · 2026Article
- Post-stroke Bone Fragility: Early Bone Loss, Risk Factors, and Recovery Considerations.Cureus · 2025Review
- Article
- Stroke-Related Sarcopenia: Pathophysiology and Diagnostic Tools.Brain & NeuroRehabilitation · 2024Review
- Safety of dry needling in stroke patients: a scoping review.European journal of physical and rehabilitation medicine · 2024Article
- Secondary Sarcopenia and Spinal Cord Injury: Clinical Associations and Health Outcomes.Journal of clinical medicine · 2024Article
- Article
- Ischemic stroke and sarcopenia have an asymmetric bidirectional relationship based on a two-sample Mendelian randomization study.Frontiers in neurology · 2024Article
- Stroke Recovery Is a Journey: Prediction and Potentials of Motor Recovery after a Stroke from a Practical Perspective.Life (Basel, Switzerland) · 2023Article
- Assessing Stroke-Related Sarcopenia in Chronic Stroke: Identification of Clinical Assessment Tools-A Pilot Study.Biomedicines · 2023Article
- Article
- Physiotherapy Efficiency in Post-stroke Upper Extremity Spasticity: TENSIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundSarcopenia, generally described as "aging-related loss of skeletal muscle mass and function", can occur secondary to a systemic disease.
aimThis project aimed to study the prevalence of sarcopenia in chronic ambulatory stroke survivors and its associated risk factors using the two most recent diagnostic criteria.
designA cross-sectional observational study.
settingA scientific laboratory. POPULATION: Chronic stroke.
methodsTwenty-eight ambulatory chronic stroke survivors (12 females; mean age=57.8±11.8 years; time after stroke=76±45 months), hand-grip strength, gait speed, and appendicular skeletal muscle mass (ASM) were measured to define sarcopenia. Risk factors, including motor impairment and spasticity, were identified using regression analysis.
resultsThe prevalence of sarcopenia varied between 18% and 25% depending on the diagnostic criteria used. A significant difference was seen in the prevalence of low hand grip strength on the affected side (96%) when compared to the contralateral side (25%). The prevalence of slow gait speed was 86% while low ASM was present in 89% of the subjects. Low ASM was marginally negatively correlated with time since stroke and gait speed, but no correlation was observed with age, motor impairment, or spasticity. ASM loss, bone loss and fat deposition were significantly greater in the affected upper limb than in the affected lower limb. Regression analyses showed that time since stroke was a factor associated with bone and muscle loss in the affected upper limb, spasticity had a protective role for muscle loss in the affected lower limb, and walking had a protective role for bone loss in the lower limb.
conclusionsThe prevalence of sarcopenia in stroke survivors is high and is a multifactorial process that is not age-related. Different risk factors contribute to muscle loss in the upper and lower limbs after stroke. CLINICAL REHABILITATION IMPACT: Clinicians need to be aware of high prevalence of sarcopenia in chronic stroke survivors. Sarcopenia is more evident in the upper than lower limbs. Clinicians also need to understand potential protective roles of some factors, such as spasticity and walking for the muscles in the lower limb.
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