Evidence map›Paper›PMID 36062186›Full record

ArticleOxidative medicine and cellular longevity2022

Astrocytic IGF-1 and IGF-1R Orchestrate Mitophagy in Traumatic Brain Injury via Exosomal miR-let-7e.

Ren Dabin, Chen Wei, Shu Liang, Cao Ke, Wang Zhihan, Zheng Ping

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. 3D-bioprinted adipose-derived stem cell-secreted GAS6Journal of nanobiotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ren DabinDepartment of Neurosurgery, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Chen WeiDepartment of Neurosurgery, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Shu LiangDepartment of Neurology, Shanghai Ninth People's Hospital, Shanghai, China.
Cao KeDepartment of Neurosurgery, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Wang ZhihanDepartment of Neurosurgery, Shanghai Pudong New Area People's Hospital, Shanghai, China.
Zheng PingDepartment of Neurosurgery, Shanghai Pudong New Area People's Hospital, Shanghai, China.ORCID https://orcid.org/0000-0002-3928-3875
Pudong New Area People's Hospital · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defective brain hormonal signaling and autophagy have been associated with neurodegeneration after brain insults, characterized by neuronal loss and cognitive dysfunction. However, few studies have linked them in the context of brain injury. Insulin-like growth factor-1 (IGF-1) is an important hormone that contributes to growth, cell proliferation, and autophagy and is also expressed in the brain. Here, we assessed the clinical data from TBI patients and performed both in vitro and in vivo experiments with proteomic and gene-chip analysis to assess the functions of IGF-1 in mitophagy following TBI. We show that reduced plasma IGF-1 is correlated with cognition in TBI patients. Overexpression of astrocytic IGF-1 improves cognitive dysfunction and mitophagy in TBI mice. Mechanically, proteomics data show that the IGF-1-related NF-

Indexed as

Brain InjuriesBrain Injuries, TraumaticInsulin-Like Growth Factor IMicroRNAsReceptor, IGF Type 1AnimalsMiceMitophagyProteomicsIgf1r protein, mouseinsulin-like growth factor-1, mouseInsulin-Like Growth Factor IMicroRNAsmirnlet7 microRNA, mouseReceptor, IGF Type 1

Identifiers

PMID36062186
PMCPMC9433209
OpenAlexW4293199950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.