ArticleFrontiers in aging neuroscience2022
The Age-adjusted Charlson Comorbidity Index predicts post-operative delirium in the elderly following thoracic and abdominal surgery: A prospective observational cohort study.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Understanding the association between pain and delirium in older hospital inpatients: systematic review and meta-analysis.Age and ageing · 2024Pooled it
- Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients.Molecular painTrial
- Are the Charlson and Elixhauser comorbidity indices reliable predictors of postoperative delirium in abdominal surgery?Surgery in practice and science · 2026Article
- Major Cardiovascular Complications of Index Kidney Transplantation Hospitalizations: A National Inpatient Sample Analysis.Transplantation direct · 2026Article
- A 5-Item Prediction Model Incorporating Pain With Neuropathic Characteristics at 2 Weeks for Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Lung Surgery: A Prospective Cohort Study.European journal of pain (London, England) · 2026Article
- The effect of early postoperative acute pain on postoperative delirium in older persons undergoing abdominal surgery: a secondary analysis of multicenter prospective data.European geriatric medicine · 2026Article
- Postoperative delirium: from bundles to precision prevention.Anesthesia and pain medicine · 2026Review
- Multimorbidity patterns are associated with postoperative delirium in older patients undergoing non-cardiac surgery: an observational study.Frontiers in medicine · 2026Article
- Relationship between sedentary time and cognitive decline in hypertensive patients-mediating role of the weight-adjusted waist circumference index.Scientific reports · 2025Article
- Creating a delirium risk assessment model for geriatric patients with femoral neck fractures through artificial intelligence techniques: a theoretical exploration.BMC neurology · 2025Article
- Predicting Postoperative Delirium in Older Patients Before Elective Surgery: Multicenter Retrospective Cohort Study.JMIR aging · 2025Article
- Development and validation of a prediction model for postoperative delirium in older patients undergoing major noncardiac surgery: protocol for a prospective multi-centre cohort study.BMC geriatrics · 2025Article
- Associations between anaesthetic dose-adjusted intraoperative EEG alpha power, processing speed, and postoperative delirium: analysis of data from three prospective studies.British journal of anaesthesia · 2025Article
- Predictors of postoperative delirium in patients undergoing radical prostatectomy: a prospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Association between educational level and postoperative delirium in older patients undergoing abdominal surgery: a two-sample cohort study.Frontiers in medicine · 2025Article
- Lipocalin-2 in preoperative cerebrospinal fluid is a biomarker for postoperative delirium after hip fracture surgery in older adults: a prospective cohort study.Frontiers in neurology · 2025Article
- Prognostic Analysis of Elderly Patients with Hepatocellular Carcinoma: an Exploration and Machine Learning Model Prediction Based on Age Stratification and Surgical Approach.Journal of hepatocellular carcinoma · 2025Article
- Evaluating the impact of Age-Adjusted Charlson Comorbidity Index on in-hospital complications in patients with femoral fracture: a retrospective cohort analysis from the MIMIC-IV 2.2 database.Frontiers in medicine · 2025Article
- Risk of sarcopenia, frailty and malnutrition as predictors of postoperative delirium in surgery.BMC geriatrics · 2024Article
- Association of preoperative cognitive frailty with postoperative complications in older patients under general anesthesia: a prospective cohort study.BMC geriatrics · 2024Article
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Abstract
Background: Post-operative delirium (POD) presents as a serious neuropsychiatric syndrome in the elderly undergoing thoracic and abdominal surgery, which is mostly associated with poor prognosis. The Age-adjusted Charlson Comorbidity Index (ACCI) has been widely recognized as an independently predictive factor for overall survival rate and mortality in various surgeries. However, no studies demonstrated the potential relationship between ACCI and POD. The current study was to explore the correlation between ACCI and POD, and determine the predictive effect of ACCI on POD in the elderly after thoracic and abdominal surgery. Materials and methods: Total 184 patients (≥60 years) who underwent thoracic and abdominal surgery from 2021.10 to 2022.5 were enrolled in this prospective observational cohort study. ACCI was calculated by weighting comorbidities and age. POD was diagnosed using Confusion Assessment Method (CAM) twice a day in the first 3 days after surgery. The Visual Analog Scale (VAS) was applied to measure pre-operative and post-operative pain at rest and in motion. All demographic and perioperative data were compared in patients with POD and without POD. ACCI and other variables were analyzed by univariate and multivariate logistic regression analysis. The characteristic curve of receiver operating characteristic (ROC) was used to further evaluate the accuracy of ACCI to predict POD. Results: Post-operative delirium was diagnosed in 36 of 184 patients included in our study. The prevalence of POD in the elderly after thoracic and abdominal surgery was 19.6%. The outcomes by multivariate regression analysis showed the independent risk factors for POD were ACCI (OR: 1.834; 95%CI: 1.434-2.344; Conclusion: Age-adjusted Charlson Comorbidity Index, pre-operative MMSE scores, serum albumin and post-operative pain were independently associated with POD in geriatric patients following thoracic and abdominal surgery. Moreover, ACCI may become an accurate indicator to predict POD early.
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