ArticleFrontiers in public health2022
Association between polyunsaturated fatty acid intake and infertility among American women aged 20-44 years.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Therapeutic Roles and Safety Profiles of Non-Vitamin Antioxidant Supplements in Female Infertility: A Narrative Review.Journal of family & reproductive health · 2026Review
- Overlapping and distinct fatty acid dysregulation in infertility and recurrent spontaneous abortion.Frontiers in endocrinology · 2026Article
- Association between high-density lipoprotein cholesterol-related inflammatory markers and female infertility: a cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES 2013-2018).BMC women's health · 2025Article
- Fertility-Enhancing Potential ofScientifica · 2025Article
- Dietary Omega-3 fatty acids inversely associated with systemic inflammatory response index (SIRI): a population-based analysis of NHANES 2005-2018.Frontiers in nutrition · 2025Article
- Predicting IVF outcomes using a logistic regression-ABC hybrid model: A proof-of-concept study on supplement associations.PloS one · 2025Article
- Association between polyunsaturated fatty acids dietary intake and pulmonary function among American children: NHANES 2007-2012.Frontiers in nutrition · 2025Article
- Review
- Association between volatile organic compounds exposure and infertility risk among American women aged 18-45 years from NHANES 2013-2020.Scientific reports · 2024Article
- Article
- Impact of dietary antioxidants on female infertility risk: evidence from NHANES.Scientific reports · 2024Article
- Association between a body shape index and female infertility: a cross-sectional study.BMC women's health · 2024Article
- Combined impact of sleep and obesity on female infertility in the NHANES 2017-2020.BMC women's health · 2024Article
- Association between Waist-Hip Ratio and Female Infertility in the United States: Data from National Health and Nutrition Examination Survey 2017-2020.Obesity facts · 2024Article
- Association between polyunsaturated fatty acid intake and estradiol levels among U.S. women.Frontiers in nutrition · 2024Article
- Association between polyunsaturated fatty acids and depression in women with infertility: a cross-sectional study based on the National Health and Nutrition Examination Survey.Frontiers in psychiatry · 2024Article
- Association between oxidative balance score and female infertility from the national health and nutrition examination survey 2013-2018.Frontiers in endocrinology · 2024Article
- Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean Diet and infertility.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Infertility is a nationwide public health priority in the U.S. However, few studies have investigated the effects of dietary intake of polyunsaturated fatty acids (PUFAs) on female infertility. This study explored the association between PUFA intake and risk of infertility. Methods: A total of 1,785 women aged 20-44 years from three National Health and Nutrition Examination Survey cycles (2013-2018) were included in this cross-sectional study. The intake of PUFAs was obtained from a 24-h dietary interview on two separate days with a 3-10-day interval, and nutrient residue models were used. Fertility status was assessed by positive response to two relative questions via a questionnaire. Logistic regression models were used and some covariates were adjusted. Results: Among all the participants, 340 (19.05%) women suffered from infertility. The intake of docosahexaenoic acid (DHA) (OR = 0.998, 95% CI 0.998, 0.009) was slightly related to the risk of infertility. In contrast, women with higher α-linolenic acid (ALA) (OR = 1.416, 95% CI 1.138, 1.763) and linoleic acid (LA) intake (OR = 1.020, 95% CI 1.002, 1.038) presented with a relatively higher risk of primary infertility. Furthermore, in 20-34-year-old women, higher omega-6/omega-3 was significant associated with the risk of infertility (OR = 1.002, 95%CI 1.000, 1.005). Conclusions: Our results suggest that PUFA intake is only slightly associated with infertility. The higher the DHA intake, the lower the risk of infertility regardless of age. In women with primary infertility, ALA and LA has negative effect.
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