ReviewFood and bioprocess technology2023
The α-Amylase and α-Glucosidase Inhibition Capacity of Grape Pomace: A Review.
Review in Food and bioprocess technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 72 citations in OpenAlex.
- Frost-induced structural modification of mulberry leaf polysaccharides enhances hypoglycemic activity and Maillard reaction inhibition in biscuits.Food chemistry: X · 2026Article
- Multitarget synthetic piperates against key drug targets of Alzheimer's and diabetes mellitus.RSC advances · 2026Article
- Article
- Investigation of the antidiabetic efficacy of Diabepat Kadha in type 2 diabetic Sprague-Dawley rats: modulation of GLUT4 expression as a molecular target.Journal of molecular histology · 2025Article
- Phytochemical Profile and α-Amylase Inhibitory Activity of Pomegranate Peel Extract: An In Silico and In Vitro Investigation.Food science & nutrition · 2025Article
- Gastrointestinal Digestion Impact on Phenolics and Bioactivity of Tannat Grape Pomace Biscuits.Molecules (Basel, Switzerland) · 2025Article
- Metabolomic and chemometric profiling of crimson grapes during drying and its impact on antidiabetic activity.NPJ science of food · 2025Article
- Comparative evaluation of the antidiabetic potential of three varieties ofToxicology reports · 2025Article
- Nutritional and Functional Values of Grape Seed Flour and Extract for Production of Antioxidative Dietary Supplements and Functional Foods.Molecules (Basel, Switzerland) · 2025Article
- Inhibitory Effects of Aqueous and Hydroalcoholic Extracts from Jatobá Coat (Plants (Basel, Switzerland) · 2025Article
- Anti alpha-amylase and alpha-glucosidase activities of the ethanolic leaf extracts ofIn silico pharmacology · 2025Article
- Grape Pomace as a Source of Phenolics for the Inhibition of Starch Digestion Enzymes: A Comparative Study and Standardization of the Efficacy.Foods (Basel, Switzerland) · 2024Article
- Synthesis of arylated tetrahydrobenzo[Future medicinal chemistry · 2024Article
- An Integrated Metabolomics Study on Antidiabetic Activity of Christia vespertilionis Leaves Extract Using Chemometric and Molecular Docking Analysis.Applied biochemistry and biotechnology · 2024Article
- Valorization of Bioactive Compounds from Lingonberry Pomace and Grape Pomace with Antidiabetic Potential.Molecules (Basel, Switzerland) · 2024Article
- Sustainable Intervention: Grape Pomace Flour Ameliorates Fasting Glucose and Mitigates Streptozotocin-Induced Pancreatic Damage in a Type 2 Diabetes Animal Model.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Turning Wastes into Resources: Red Grape Pomace-Enriched Biscuits with Potential Health-Promoting Properties.Foods (Basel, Switzerland) · 2024Article
- Anti-Inflammatory, Antidiabetic, and Antioxidant Properties of Extracts Prepared from Pinot Noir Grape Marc, Free and Incorporated in Porous Silica-Based Supports.Molecules (Basel, Switzerland) · 2024Article
- Grape Pomace-Advances in Its Bioactivity, Health Benefits, and Food Applications.Foods (Basel, Switzerland) · 2024Review
- Comparative Analysis of Different Natural Polymers as Coating Agents for Freeze-Dried Microencapsulation ofTheScientificWorldJournal · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of functional foods is gaining more importance due to its role in maintaining a healthy status and preventing some metabolic diseases. The control of diabetes, in particular type-2 (T2DM), could be considered a big challenge since it involves other factors such as eating habits. From the pharmacological point of view, inhibiting digestive enzymes, such as α-amylase and α-glucosidase, is one of the mechanisms mainly used by synthetic drugs to control this disease; however, several side effects are described. For that reason, using bioactive compounds may appear as an alternative without presenting the complications synthetic drugs available on the market have. The winemaking industry generates tons of waste annually, and grape pomace (GP) is the most important. GP is recognized for its nutritional value and as a source of bioactive compounds that are helpful for human health. This review highlights the importance of GP as a possible source of α-amylase and α-glucosidase inhibitors. Also, it is emphasized the components involved in this bioactivity and the possible interactions among them. Especially, some phenolic compounds and fiber of GP are the main ones responsible for interfering with the human digestive enzymes. Preliminary studies in vitro confirmed this bioactivity; however, further information is required to allow the specific use of GP as a functional ingredient inside the market of products recommended for people with diabetes. Graphical abstract:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.