Evidence map›Paper›PMID 36062008›Full record

ArticleFrontiers in neurology2022

Neurological and psychological effects of long COVID in a young population: A cross-sectional study.

Cristiana Alessia Guido, Fabio Lucidi, Fabio Midulla, Anna Maria Zicari, Elena Bove, Federica Avenoso, Ilaria Amedeo, Enrica Mancino, Raffaella Nenna, Giovanna De Castro and 7 more

Abstract read
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cristiana Alessia GuidoDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Fabio LucidiDepartment of Developmental and Social Psychology, Sapienza University of Rome, Rome, Italy.
Fabio MidullaDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Anna Maria ZicariDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Elena BoveDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Federica AvenosoDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Ilaria AmedeoDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Enrica MancinoDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Raffaella NennaDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Giovanna De CastroDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Martina CapponiDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Bianca Laura CinicolaDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Giulia BrindisiDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Flavia GrisoniDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Manuel MurcianoDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Alberto SpaliceDepartment of Maternal Sciences, Sapienza University of Rome, Rome, Italy.
Long-Covid Group of Department of Maternal Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: We evaluated the long-term clinical status of pediatric patients after testing positive for COVID-19. We hypothesized that there are similar symptoms to those that have been described in adults and children and that pediatric patients with neurophysiologic symptoms still present 3-5 months after infection have psychological consequences that interfere with their adaptive functioning. Method: We recruited 322 COVID-19-positive pediatric patients, between 1.5 and 17 years old, from the outpatient clinic for COVID-19 follow-up. Neurological symptoms were analyzed at onset, after 1 month, and after 3-5 months. A psychological assessment with standardized questionnaires was also conducted to determine the impact of the disease. Results: At the onset of COVID-19, 60% of the total sample exhibited symptoms; this decreased after 1 month (20%) but stabilized 3-5 months after disease onset (22%). Prevailing long-COVID neurological symptoms were headache, fatigue, and anosmia. In the 1.5-5-year-old subgroup, internalizing problems emerged in 12% of patients. In the 6-18-year-old subgroup, anxiety and post-traumatic stress showed significant associations with neurological symptoms of long COVID. Conclusions: These data demonstrate that long COVID presents various broad-spectrum symptoms, including psychological and long-lasting cognitive issues. If not treated, these symptoms could significantly compromise the quality of life of children and adolescents.

Indexed as

adolescentschildrenCNS (central nervous system)COVID-19 (coronavirus disease 2019)long-COVID syndromepediatricspsychological effectsSARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)

Identifiers

PMID36062008
PMCPMC9428748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.