ArticleFrontiers in neurology2022
Sleep alterations following COVID-19 are associated with both neuroinflammation and psychological disorders, although at different times.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- Systematic review and evidence gap mapping of biomarkers associated with neurological manifestations in patients with COVID-19.Journal of neurology · 2024Pooled it
- A Multidimensional Assessment of Sleep Disorders in Long COVID Using the Alliance Sleep Questionnaire.Healthcare (Basel, Switzerland) · 2025Article
- First episode of psychiatric and neuropsychiatric disease among patients infected with COVID-19: A scoping review.PCN reports : psychiatry and clinical neurosciences · 2025Review
- Relationship between longer sleep and serum neurofilament light chain in american adults: evidence from the 2013-2014 US national health and nutrition examination survey.BMC public health · 2024Article
- Using the ClinFIT COVID-19 Instrument to Assess the Functional Impairments Specific to Post-COVID-19 Patients in Romania.Diagnostics (Basel, Switzerland) · 2024Article
- Quality of Sleep and Mental Symptoms Contribute to Health-Related Quality of Life after COVID-19 Pneumonia, a Follow-Up Study of More than 2 Years.Biomedicines · 2024Article
- Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection.BMC medicine · 2024Article
- Sleep quality in individuals with post-COVID-19 condition: Relation with emotional, cognitive and functional variables.Brain, behavior, & immunity - health · 2024Article
- Cognitive impairment after long COVID-19: current evidence and perspectives.Frontiers in neurology · 2023Article
- Persistent olfactory dysfunction associated with poor sleep quality and anxiety in patients with long COVID.Frontiers in neuroscience · 2023Article
- Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life.Frontiers in neurology · 2022Review
- The effect of hyperbaric oxygen therapy on sleep quality across diverse patient populations.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: By the end of 2019, severe acute respiratory syndrome coronavirus 2 rapidly spread all over the world impacting mental health and sleep habits. Insomnia, impaired sleep quality, and circadian rhythm alterations were all observed during the pandemic, especially among healthcare workers and in patients with acute and post-acute COVID-19. Sleep disruption may induce a pro-inflammatory state associated with an impairment of immune system function. Objective: We investigated the relationship between sleep alterations, psychological disorders, and inflammatory blood biomarkers in patients with post-acute COVID-19. Methods: We enrolled 47 subjects diagnosed with COVID-19 pneumonia at Results: Prevalence of insomnia increased from 10.6% up to 27.3% after COVID-19. Poor sleep quality was found in 41.5% of patients at both study visits. At T1 follow-up, poor sleepers showed higher levels of neurofilament light chain, vascular cell adhesion molecule 1, and interleukin 10; no significant associations were found between sleep quality and psychological disorders. At T2 follow-up, lower sleep quality was associated with higher levels of vascular cell adhesion molecule 1 and interleukin 8, but also with higher scores for anxiety, depression, and post-traumatic stress disorder. Conclusion: Our results suggest an association of poor sleep quality with both psychological disorders and neuroinflammation, although at different times, in previously hospitalized patients with moderate-to-critical COVID-19.
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