ArticleTheScientificWorldJournal2022
The Association of Obesity and the Antiaging Humoral Factor Klotho in Middle-Aged and Older Adults.
Article in TheScientificWorldJournal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Influence of Klotho Protein Levels in Obesity and Sarcopenia: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Evaluation of plasma Alpha klotho levels in obese cases.Journal of medical biochemistry · 2026Article
- Associations Between Klotho/FGF-Related Protein Expression in Peripheral Blood Mononuclear Cells, Inflammation, and Muscle Function in Middle-Aged Adults with Obesity: A Pilot Study.International journal of molecular sciences · 2026Article
- Anti-aging protein α-Klotho is potential for reducing comorbidity risk of cardiometabolic diseases in vulnerable populations and enhancing long-term prognosis.Scientific reports · 2025Article
- Metabolically healthy across body mass index categories in relation to serum Klotho levels: a population-based study.Frontiers in endocrinology · 2025Article
- The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking.Frontiers in public health · 2025Article
- Correlation of the weight-adjusted waist circumference index with Klotho in the United States: differences by sex.Scientific reports · 2024Article
- Gender-specific association between circulating serum Klotho and metabolic components in adults.BMC endocrine disorders · 2024Article
- Association between weight change and serum anti-aging protein α-Klotho: a cross-sectional study in middle-aged and older adults.Scientific reports · 2024Article
- Relationship between uric acid to high-density cholesterol ratio (UHR) and circulating α-klotho: evidence from NHANES 2007-2016.Lipids in health and disease · 2024Article
- Associations between the TyG index and the ɑ-Klotho protein in middle-aged and older population relevant to diabetes mellitus in NHANES 2007-2016.Lipids in health and disease · 2024Article
- Involvement of Single Nucleotide Variants in theDiabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity.Frontiers in aging neuroscience · 2024Review
- Dietary caffeine and its negative link to serum Klotho concentrations: evidence from the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2024Article
- Association of Dietary Vitamin C Consumption with Serum Klotho Concentrations.Foods (Basel, Switzerland) · 2023Article
- Article
- Change in circulating klotho in response to weight loss, with and without exercise, in adults with overweight or obesity.Frontiers in aging · 2023Article
- Higher levels of serum α-Klotho are longitudinally associated with less central obesity in girls experiencing weight gain.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Previous studies have reported conflicting results regarding the relationship between obesity and the antiaging humoral factor klotho. Thus, the present study aimed to examine the association of anthropometric measurements, weight history change, and vitamin D status with serum klotho levels. Methods: The National Health and Nutrition Examination Survey data were used to compare sex-specific logarithm transformed serum klotho levels across standardized anthropometric measurements and weight change history in subjects aged 40-79 years. The baseline measured height, and self-reported weight were used to calculate the body mass index (BMI) at two-time intervals: age 25 and ten years before the measured BMI. Subjects were then categorized as never obese, obese to nonobese, nonobese to obese, and always obese. Results: Of 4,971 participants, the prevalence of general obesity was 41%, and abdominal obesity (waist circumference ≥88 cm) was present in 75% of women. Overall, lower serum klotho levels were seen in older adults, men, nonsmokers, alcohol users, and those with an estimated glomerular filtration rate (eGFR) < 60 ml/min. Multivariate models demonstrated that general and abdominal obesity in women was inversely associated with serum klotho levels. Moreover, women who developed obesity from age 25 and ten years before the baseline BMI had significantly lower mean klotho levels at 765.0 and 757.4 pg/ml compared with 820.5 pg/ml ( Conclusions: Obesity among women was significantly and inversely associated with serum klotho levels. Similarly, women who developed obesity during their lifetime had consistently lower klotho levels than their never-obese counterparts.
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