Evidence map›Paper›PMID 36061872›Full record

ReviewFrontiers in cellular and infection microbiology2022

Are all antibiotic persisters created equal?

Michael W Shultis, Claire V Mulholland, Michael Berney

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. A new Persister Enrichment Model inbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Characterization ofMicroorganisms · 2024
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael W ShultisDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, United States.
Claire V MulhollandDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, United States.
Michael BerneyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, United States.
Albert Einstein College of Medicine · US

Funding

Training in HIV/AIDS Pathogenesis; Basic and Translational ResearchT32AI007501 · NIAID · YESHIVA UNIVERSITY · PI PRASAD, VINAYAKA R. · 1995 to 2024
$6.6M
Eradicating persistent M. tuberculosis by synthetic lethality of terminal respiratory oxidasesR01AI139465 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERNEY, MICHAEL · 2019 to 2023
$3.2M
Identification of new inhibitors of essential functions in M. tuberculosis by high-throughput metabolic profilingR01AI173328 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Michael Berney · 2023 to 2026
$2.6M
NIAID NIH HHS R01 AI139465NIAID NIH HHS R01 AI173328NIAID NIH HHS T32 AI007501
6 · The paper itself

Abstract

Antibiotic persisters are a sub-population of bacteria able to survive in the presence of bactericidal antibiotic despite the lack of heritable drug resistance mechanisms. This phenomenon exists across many bacterial species and is observed for many different antibiotics. Though these bacteria are often described as "multidrug persisters" very few experiments have been carried out to determine the homogeneity of a persister population to different drugs. Further, there is much debate in the field as to the origins of a persister cell. Is it formed spontaneously? Does it form in response to stress? These questions are particularly pressing in the field of

Indexed as

Anti-Bacterial AgentsMycobacterium tuberculosisAnti-Bacterial Agentsmultidrugmycobacteriapersistencepersisterresistancetolerancetuberculosis

Identifiers

PMID36061872
PMCPMC9428696
OpenAlexW4292317564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.