Evidence map›Paper›PMID 36061696›Full record

ArticleACS omega2022

Steric Effects in the Deposition Mode and Drug-Delivering Efficiency of Nanocapsule-Based Multilayer Films.

Li Xu, Zihan Chu, Jianhua Zhang, Tingwei Cai, Xingxing Zhang, Yinzhao Li, Hailong Wang, Xiaochen Shen, Raymond Cai, Haifeng Shi and 3 more

Abstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Li XuInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.ORCID https://orcid.org/0000-0002-8150-7975
Zihan ChuInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Jianhua ZhangN.O.D Topia (GuangZhou) Biotechnology Co., Ltd., Guangzhou, Guangdong 510599, China.
Tingwei CaiGuangdong Jiabo Pharmaceutical Co., Qingyuan, Guangdong 511517, China.
Xingxing ZhangInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Yinzhao LiInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Hailong WangInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Xiaochen ShenChina Tobacco Jiangsu Industrial Co., Ltd., Nanjing, Jiangsu 210023, China.
Raymond CaiInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Haifeng ShiInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Chunyin ZhuInstitute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Jia PanNovo Nordisk Research Center-Indianapolis, Inc., Indianapolis, Indiana 46241, United States.
Donghui PanJiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using surface-initiated atom transfer radical polymerization (ATRP), block polymers with a series of quaternization degrees were coated on the surface of silica nanocapsules (SNCs) by the "grafting-from" technique. Molnupiravir, an antiviral medicine urgently approved for the treatment of SARS-CoV-2, was encapsulated in polymer-coated SNCs and further incorporated into well-defined films with polystyrene sulfonate (PSS) homopolymers by layer-by-layer (LBL) self-assembly via electrostatic interactions. We investigated the impact of the quaternization degree of the polymers and steric hindrance of functional groups on the growth mode, swelling/deswelling transition, and drug-delivering efficiency of the obtained LBL films. The SNCs were derived from coronas of parent block polymers of matched molecular weights-poly(

Identifiers

PMID36061696
PMCPMC9434745

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.