Evidence map›Paper›PMID 36061536›Full record

ArticleFrontiers in cardiovascular medicine2022

Role of serum C1q/TNF-related protein family levels in patients with acute coronary syndrome.

Yixiang Liu, Chen Wei, Zhenjiang Ding, Enhong Xing, Zhuoyan Zhao, Fei Shi, Yanan Tian, Ying Zhang, Wenjun Fan, Lixian Sun

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Review
  6. Unveiling the roles of CTRP family in cardiac remodeling.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yixiang LiuDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Chen WeiDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Zhenjiang DingDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Enhong XingCentral Laboratory, Chengde Medical University Affiliated Hospital, Chengde, China.
Zhuoyan ZhaoDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Fei ShiDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Yanan TianDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Ying ZhangDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Wenjun FanDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.
Lixian SunDepartment of Cardiology, Chengde Medical University Affiliated Hospital, Chengde, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The C1q/TNF-related protein (CTRP) family affects inflammation regulation, energy metabolism, and insulin signaling. However, their role in acute coronary syndrome (ACS) development is unclear. In this cross-sectional study, we aimed to investigate the association between CTRP family and ACS. Methods: We enrolled 289 consecutive inpatients with suspected ACS. Serum CTRP family, tumor necrosis factor-α (TNF-α), and adiponectin (ADP) levels were assessed using enzyme-linked immunosorbent assay (ELISA). Multivariate logistic regression and subgroup analyses were used to assess risk factors for ACS. Spearman's tests were used to analyze correlations between CTRP family and continuous variables. Results: Serum CTRP family levels differed significantly between ACS and Control groups ( Conclusion: CTRP1 and CTRP5 were identified as independent ACS risk factors, whereas CTRP2, CTRP3, CTRP9, CTRP12, CTRP13, and CTRP15 were independent protective factors for ACS. CTRP family, especially CTRP1 and CTRP3 could be novel potential clinical biomarkers of ACS.

Indexed as

acute coronary syndromeC1q/TNF-related proteincoronary angiographydiagnosisGensini score

Identifiers

PMID36061536
PMCPMC9437344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.