Evidence map›Paper›PMID 36061500›Full record

ArticleFrontiers in human neuroscience2022

Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate.

Ezra E Smith, Ki Sueng Choi, Ashan Veerakumar, Mosadoluwa Obatusin, Bryan Howell, Andrew H Smith, Vineet Tiruvadi, Andrea L Crowell, Patricio Riva-Posse, Sankaraleengam Alagapan and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05773755 (Deep Brain Stimulation for Treatment Resistant Depression), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05773755 narecruitingnot on this mapstarted 2023, after this paper: background citation

Deep Brain Stimulation for Treatment Resistant Depression: Exploration of Local Field Potentials (LFPs) With the Medtronic Percept PC System

TypeinterventionalSponsorHelen Mayberg, MDRan2023 to 2028Enrolled20ConditionsMajor Depressive Disorder, Treatment Resistant DepressionArmsMedtronic Percept PC DBS system
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Advances in Deep Brain Stimulation: From Mechanisms to Applications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ezra E SmithPrivate Practice, Tucson, AZ, Pima.
Ki Sueng ChoiDepartments of Psychiatry, Neuroscience, Neurology, Neurosurgery and Radiology, Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Ashan VeerakumarDepartment of Psychiatry, Schulich School of Medicine and Dentistry, London, ON, Canada.
Mosadoluwa ObatusinDepartments of Psychiatry, Neuroscience, Neurology, Neurosurgery and Radiology, Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Bryan HowellDepartment of Biomedical Engineering, Duke University, Durham, NC, United States.
Andrew H SmithDepartments of Psychiatry, Neuroscience, Neurology, Neurosurgery and Radiology, Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Vineet TiruvadiEmory University School of Medicine, Atlanta, GA, United States.
Andrea L CrowellDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Patricio Riva-PosseDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Sankaraleengam AlagapanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Christopher J RozellSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Helen S MaybergDepartments of Psychiatry, Neuroscience, Neurology, Neurosurgery and Radiology, Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Allison C WatersDepartments of Psychiatry, Neuroscience, Neurology, Neurosurgery and Radiology, Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Funding

Electrophysiological Biomarkers to Optimize DBS for DepressionUH3NS103550 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MAYBERG, HELEN S, RIVA-POSSE, PATRICIO · 2017 to 2023
$7.7M
Tractography-Activation Models for Neuropsychiatric Deep StimulationR01MH102238 · NIMH · DUKE UNIVERSITY · PI MCINTYRE, CAMERON · 2014 to 2025
$4.5M
NINDS NIH HHS UH3 NS103550
6 · The paper itself

Abstract

Precision targeting of specific white matter bundles that traverse the subcallosal cingulate (SCC) has been linked to efficacy of deep brain stimulation (DBS) for treatment resistant depression (TRD). Methods to confirm optimal target engagement in this heterogenous region are now critical to establish an objective treatment protocol. As yet unexamined are the time-frequency features of the SCC evoked potential (SCC-EP), including spectral power and phase-clustering. We examined these spectral features-evoked power and phase clustering-in a sample of TRD patients (

Indexed as

deep brain stimulationinter-trial phase clusteringperturbation mappingsingle pulse electrical stimulationstimulation evoked potentialsubcallosal cingulatetime frequency analysestreatment resistant depression (TRD)

Identifiers

PMID36061500
PMCPMC9433578

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.