Evidence map›Paper›PMID 36061342›Full record

ArticleJACC. Basic to translational science2022

Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress.

Yihong Chen, Junyan Shen, Anna Hultgårdh Nilsson, Isabel Goncalves, Andreas Edsfeldt, Gunnar Engström, Suneela Zaigham, Olle Melander, Marju Orho-Melander, Uwe Rauch and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Sex differences in proteomics of cardiovascular disease -International journal of cardiology. Heart & vasculature · 2025
    Article
  4. Angiotensin IV does not exert prothrombotic effectsJournal of molecular and cellular cardiology plus · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yihong ChenDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Junyan ShenDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Anna Hultgårdh NilssonDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Isabel GoncalvesInstitute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Andreas EdsfeldtDepartment of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Gunnar EngströmDepartment of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Suneela ZaighamDepartment of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Olle MelanderDepartment of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Marju Orho-MelanderDepartment of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Uwe RauchDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Shreenidhi M VenurajuBritish Cardiac Research Trust, London, United Kingdom.
Avijit LahiriBritish Cardiac Research Trust, London, United Kingdom.
Chun LiangDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Jan NilssonDepartment of Experimental Medical Science, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.

Indexed as

apoptosisatherosclerosisAU, arbitrary unitBrdU, bromodeoxyuridineCVD, cardiovascular diseaseEC, endothelial cellendothelial cellsgrowth factorsHCASMC, human coronary artery smooth muscle cellHDL, high-density lipoproteinHGF, hepatocyte growth factorHUVEC, human umbilical cord endothelial cellICD-9, International Classification of Diseases-9th RevisionIL, interleukininjuryLDL, low-density lipoproteinMMP, matrix metalloproteinasemRNA, messenger RNAmyocardial infarctionPlGF, placental growth factorsi-HGF, hepatocyte growth factor small interfering RNAsiRNA, small interfering RNASMC, smooth muscle cells, solubleTGF, transforming growth factorTNF, tumor necrosis factorTRAIL, tumor necrosis factor–related apoptosis-inducing ligandVEGF, vascular endothelial growth factor

Identifiers

PMID36061342
PMCPMC9436817

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.