Evidence map›Paper›PMID 36061154›Full record

ArticleAnnals of gastroenterology

Significance of granulomas in the outcomes of Crohn's disease patients.

Marie Christelle Saade, Hisham Wehbe, Fadi H Mourad, Mohammad Hosni, Fadi F Francis, Maha Makki, David G Binion, Hani Tamim, Francis A Farraye, Talha Malik and 1 more

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Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marie Christelle SaadeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon (Marie Christelle Saade, Hisham Wehbe, Fadi H. Mourad, Mohammad Hosni, Fadi F. Francis, Jana G. Hashash).
Hisham WehbeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon (Marie Christelle Saade, Hisham Wehbe, Fadi H. Mourad, Mohammad Hosni, Fadi F. Francis, Jana G. Hashash).
Fadi H MouradDivision of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon (Marie Christelle Saade, Hisham Wehbe, Fadi H. Mourad, Mohammad Hosni, Fadi F. Francis, Jana G. Hashash).
Mohammad HosniDivision of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon (Marie Christelle Saade, Hisham Wehbe, Fadi H. Mourad, Mohammad Hosni, Fadi F. Francis, Jana G. Hashash).
Fadi F FrancisDivision of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon (Marie Christelle Saade, Hisham Wehbe, Fadi H. Mourad, Mohammad Hosni, Fadi F. Francis, Jana G. Hashash).
Maha MakkiDepartment of Internal Medicine, Clinical Research Institute, American University of Beirut, Beirut, Lebanon (Maha Makki, Hani Tamim).
David G BinionDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA (Fadi F. Francis, David G. Binion).
Hani TamimDepartment of Internal Medicine, Clinical Research Institute, American University of Beirut, Beirut, Lebanon (Maha Makki, Hani Tamim).
Francis A FarrayeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA (Francis A. Farraye, Jana G. Hashash).
Talha MalikDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Abu Dhabi, United Arab Emirates (Talha Malik).
Jana G HashashDivision of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon (Marie Christelle Saade, Hisham Wehbe, Fadi H. Mourad, Mohammad Hosni, Fadi F. Francis, Jana G. Hashash).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The presence of granulomas in the gastrointestinal (GI) tract is one of the characteristic histologic features of Crohn's disease (CD). The clinical significance of granulomas remains unclear. In this study, we aimed to determine whether the presence of granulomas on endoscopic pinch biopsy or surgical resection from the upper or lower GI tract is associated with worse outcomes among patients with CD. Methods: This was a retrospective chart review of patients with CD evaluated at a tertiary care center between 1996 and 2019. Patients were divided into 2 groups based on the presence or absence of granulomas on GI histology. Clinical and laboratory data, and outcomes of interest, were obtained from the electronic medical records. Patients' characteristics and outcomes were compared between the 2 groups. Results: A total of 237 patients were included in our study; 41 (17.3%) had granulomas on their biopsy/resection specimen. The presence of granulomas in the GI tract was significantly associated with the development of intra-abdominal abscesses and/or fistulas (P=0.037), greater utilization of immunomodulators (P=0.029), and greater use of immunosuppressive medications (immunomodulator and/or biologic therapy) (P=0.015). No significant differences were found between the 2 groups in terms of number of hospitalizations, presence of perianal disease, intestinal resection, mean age, mean age at initial diagnosis of CD, duration of disease, sex, or smoking history. Conclusions: The presence of granulomas in the GI tract of CD patients may serve as a prognostic biomarker of worse disease severity. Larger studies are needed to better validate this finding.

Indexed as

Crohn’s diseasedisease severitygranulomaimmunosuppressive medicationsprognosis

Identifiers

PMID36061154
PMCPMC9399581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.