Evidence map›Paper›PMID 36060991›Full record

ArticleHeliyon2022

Insights on possible interplay between epithelial-mesenchymal transition and T-type voltage gated calcium channels genes in metastatic breast carcinoma.

Fawziya A E Ragab Ibrahim, Zain Ulabdeen Naser Hussein, Amany I Yousef, Nadia Ahmed Abd El Moneim, Amr Mahmoud Hussein, Ayman Farouk Mohammad Ahmed, Noha Mohamed Ragab, O Al-Masry

Abstract read
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fawziya A E Ragab IbrahimDepartment of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, Egypt.
Zain Ulabdeen Naser HusseinDepartment of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, Egypt.
Amany I YousefDepartment of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, Egypt.
Nadia Ahmed Abd El MoneimDepartment of Cancer Management and Research, Medical Research Institute, University of Alexandria, Egypt.
Amr Mahmoud HusseinDepartment of Cancer Management and Research, Medical Research Institute, University of Alexandria, Egypt.
Ayman Farouk Mohammad AhmedDepartment of Experimental and Clinical Surgery, Medical Research Institute, University of Alexandria, Egypt.
Noha Mohamed RagabDepartment of Pathology, Medical Research Institute, University of Alexandria, Egypt.
O Al-MasryDepartment of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the most common life-threatening malignancy amongst women with high incidence worldwide. In Egypt, it is the most known malignancy amongst females. Epithelial-mesenchymal transition (EMT) participates in breast tumors' invasiveness, and metastasis, but the process is poorly understood. The involvement of voltage-gated calcium channels signaling in EMT has not yet been fully explored. Therefore, the aim of this study was to investigate the possible role of T-type calcium channels in metastasis and EMT among breast cancer patients. The study was carried out on 48 female breast cancer patients who were divided into two groups; metastatic and non-metastatic. qRT-PCR was employed to measure the expression of EMT marker genes (

Indexed as

Breast cancerCACNA1G NcadherinCACNA1HCACNA1IE- cadherinEMTMetastasisT-type VGCCs

Identifiers

PMID36060991
PMCPMC9434037

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.