Evidence map›Paper›PMID 36060932›Full record

ArticleFrontiers in endocrinology2022

Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy.

Chenxiang Wang, Yibin Sun, Wenjing Liu, Yang Liu, Sualiha Afzal, Jahnavi Grover, Dennis Chang, Gerald Münch, Chun Guang Li, Shiling Lin and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Chenxiang WangFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yibin SunFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Wenjing LiuFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yang LiuNICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
Sualiha AfzalSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Jahnavi GroverSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Dennis ChangNICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
Gerald MünchSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Chun Guang LiNICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
Shiling LinFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Jianyu ChenFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yiping ZhangThird Institute of Oceanography, Technical Innovation Center for Utilization of Marine Biological Resources, Ministry of Natural Resources, Xiamen, China.
Zaixing ChengFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yanxiang LinFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Yanfang ZhengFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Mingqing HuangFujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Xian ZhouNICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
Fujian University of Traditional Chinese Medicine · CNCamden and Campbelltown Hospitals · AUWestern Sydney University · AUFujian Institute of Oceanography · CNWestmead Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular function. The cellular protective effects of Cur, Bai and Cur+Bai (1:1,

Indexed as

CurcuminDiabetes MellitusDiabetic AngiopathiesAnimalsFlavanonesHydrogen PeroxideRatsRats, WistarbaicaleinCurcuminFlavanonesHydrogen Peroxidebaicaleincurcumindiabetic angiopathyendothelial dysfunctionMAPK/JNKnetwork pharmacologyNrf2-HO-1synergy

Identifiers

PMID36060932
PMCPMC9433877
OpenAlexW4292416577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.