Evidence map›Paper›PMID 36060810›Full record

ArticleFrontiers in cell and developmental biology2022

In depth functional characterization of human induced pluripotent stem cell-derived beta cells

Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Toshiaki Sawatani, Nathalie Pachera, Ying Cai, Chiara Vinci, Enrico Virgilio and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

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  16. Advanced therapy to cure diabetes: mission impossible is now possible?Frontiers in cell and developmental biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Federica FantuzziULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Sanna ToivonenULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Andrea Alex SchiavoULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Heeyoung ChaeInstitut de Recherche Expérimentale et Clinique, Pôle d'Endocrinologie, Diabète et Nutrition, Université Catholique de Louvain, Brussels, Belgium.
Mohammad TariqInstitut de Recherche Expérimentale et Clinique, Pôle d'Endocrinologie, Diabète et Nutrition, Université Catholique de Louvain, Brussels, Belgium.
Toshiaki SawataniULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Nathalie PacheraULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Ying CaiULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Chiara VinciULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Enrico VirgilioULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Laurence LadriereULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Mara SuleimanDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Piero MarchettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Jean-Christophe JonasInstitut de Recherche Expérimentale et Clinique, Pôle d'Endocrinologie, Diabète et Nutrition, Université Catholique de Louvain, Brussels, Belgium.
Patrick GilonInstitut de Recherche Expérimentale et Clinique, Pôle d'Endocrinologie, Diabète et Nutrition, Université Catholique de Louvain, Brussels, Belgium.
Décio L EizirikULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Mariana Igoillo-EsteveULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Miriam CnopULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.
Université Libre de Bruxelles · BEUCLouvain · BEUniversity of Pisa · ITUniversity of Parma · IT

Funding

The Integrated Stress Response in Human Islets During Early T1DU01DK127786 · NIDDK · UNIVERSITY OF CHICAGO · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2020 to 2025
$7.1M
iPLA2beta-mediated alternative splicing and -cell death in type 1 diabetesR01DK126444 · NIDDK · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., EIZIRIK, DECIO LAKS · 2021 to 2024
$2.0M
NIDDK NIH HHS R01 DK126444NIDDK NIH HHS U01 DK127786
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

aggregate, beta cellhuman induced pluripotent stem cellinsulin secretionisletmicrowell

Identifiers

PMID36060810
PMCPMC9428245
OpenAlexW4292295602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.