Evidence map›Paper›PMID 36060791›Full record

ArticleMatrix biology plus2022

Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice.

Lauren K Wareham, John Kuchtey, Hang-Jing Wu, Evan Krystofiak, Yusheng Wu, Cynthia A Reinhart-King, Rachel W Kuchtey

Open access · goldAbstract read
In one paragraph

Article in Matrix biology plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Protein misfolding and mitochondrial dysfunction in glaucoma.Frontiers in cell and developmental biology · 2025
    Review
  9. Review
  10. In Search of Mouse Models for Exfoliation Syndrome.American journal of ophthalmology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lauren K WarehamVanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
John KuchteyVanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Hang-Jing WuVanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Evan KrystofiakCell Imaging Shared Resource, Vanderbilt University, Nashville, TN, USA.
Yusheng WuDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Cynthia A Reinhart-KingDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Rachel W KuchteyVanderbilt Eye Institute, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Targeting Tissue Biomechanics for Treatment of GlaucomaR01EY020894 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KUCHTEY, RACHEL W · 2010 to 2025
$6.4M
NEI NIH HHS R01 EY020894
6 · The paper itself

Abstract

Lysyl oxidase-like 1 encoded by the

Indexed as

Atomic force microscopyExfoliation glaucomaExtracellular matrixLysyl oxidase-like 1Peripapillary scleraTransmission electron microscopy

Identifiers

PMID36060791
PMCPMC9436796
OpenAlexW4292822038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.