Evidence map›Paper›PMID 36060690›Full record

ArticleFrontiers in physiology2022

Aberrant activation of KRAS in mouse theca-interstitial cells results in female infertility.

Penghao Sun, Hongliang Wang, Lingyun Liu, Kaimin Guo, Xian Li, Yin Cao, Chemyong Ko, Zi-Jian Lan, Zhenmin Lei

Abstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Penghao SunDepartment of Andrology, The First Hospital of Jilin University, Changchun, China.
Hongliang WangDepartment of Andrology, The First Hospital of Jilin University, Changchun, China.
Lingyun LiuDepartment of Andrology, The First Hospital of Jilin University, Changchun, China.
Kaimin GuoDepartment of Andrology, The First Hospital of Jilin University, Changchun, China.
Xian LiDepartment of OB/GYN, University of Louisville School of Medicine, Louisville, KY, United States.
Yin CaoDepartment of Andrology, The First Hospital of Jilin University, Changchun, China.
Chemyong KoDepartment of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Zi-Jian LanBirth Defects Center, University of Louisville School of Dentistry, Louisville, KY, United States.
Zhenmin LeiDepartment of OB/GYN, University of Louisville School of Medicine, Louisville, KY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KRAS plays critical roles in regulating a range of normal cellular events as well as pathological processes in many tissues mediated through a variety of signaling pathways, including ERK1/2 and AKT signaling, in a cell-, context- and development-dependent manner. The

Indexed as

Bmp7infertilityKRASovulationtheca cell

Identifiers

PMID36060690
PMCPMC9437434

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.