ArticleFrontiers in physiology2022
Human CSF movement influenced by vascular low frequency oscillations and respiration.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Quantifying Cardiac, Respiratory, and Low Frequency Components of CSF Motion From fMRI Inflow Effects.Magnetic resonance in medicine · 2026Article
- Task-Evoked Functional Activation and Coupling With CSF Flow Detected in the Human Brain With Ultrashort Echo Time fMRI at 7 T.NMR in biomedicine · 2026Article
- Functional Magnetic Resonance Imaging Signal Typically Viewed as "Noise" Has Clinical Relevance in Psychiatry.Biological psychiatry global open science · 2026Article
- High-temporal resolution metabolic connectivity resolved by component-based noise correction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Ultrasonic modulation of brain glymphatic transport: from observations to theranostic applications.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- Sleep-dependent alterations in anterior cingulate cortex excitation-inhibition balance link alterations in BOLD-CSF coupling to cognitive performance in obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Dynamic DWI detects respiratory modulation of brain parenchymal hydrodynamics.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Orchestrating brain fluid dynamics: circadian regulation of CSF, glymphatic exchange, and waste clearance.Frontiers in cell and developmental biology · 2026Review
- Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system.Frontiers in physiology · 2026Article
- Quantitative evaluation of low-frequency oscillations using real-time phase-contrast MRI during drowsiness.Fluids and barriers of the CNS · 2025Article
- Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics.Nature neuroscience · 2025Article
- HyPER: Region-specific hypersampling of fMRI to resolve low-frequency, respiratory, and cardiac pulsations, revealing age-related differences.NeuroImage · 2025Article
- Article
- Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Association between low-frequency oscillations in blood pressure variability and brain age derived from neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Amplitude fluctuations of cerebrovascular oscillations and CSF movement desynchronize during NREM3 sleep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Biological Fluid Flows: Signaling Mediums for Circadian Timing.Journal of biological rhythms · 2025Review
- Assessing the feasibility of a new approach to measure the full spectrum of cerebrospinal fluid dynamics within the human brain using MRI: insights from a simulation study.Interface focus · 2025Article
- Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow.bioRxiv : the preprint server for biology · 2024Article
- Coupled pulsatile vascular and paravascular fluid dynamics in the human brain.Fluids and barriers of the CNS · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Cerebrospinal fluid (CSF) movement through the pathways within the central nervous system is of high significance for maintaining normal brain health and function. Low frequency hemodynamics and respiration have been shown to drive CSF in humans independently. Here, we hypothesize that CSF movement may be driven simultaneously (and in synchrony) by both mechanisms and study their independent and coupled effects on CSF movement using novel neck fMRI scans. Caudad CSF movement at the fourth ventricle and hemodynamics of the major neck blood vessels (internal carotid arteries and internal jugular veins) was measured from 11 young, healthy volunteers using novel neck fMRI scans with simultaneous measurement of respiration. Two distinct models of CSF movement (1. Low-frequency hemodynamics and 2. Respiration) and possible coupling between them were investigated. We show that the dynamics of brain fluids can be assessed from the neck by studying the interrelationships between major neck blood vessels and the CSF movement in the fourth ventricle. We also demonstrate that there exists a cross-frequency coupling between these two separable mechanisms. The human CSF system can respond to multiple coupled physiological forces at the same time. This information may help inform the pathological mechanisms behind CSF movement-related disorders.
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