Evidence map›Paper›PMID 36060674›Full record

ArticleFrontiers in physiology2022

Mitochondrial translocator protein deficiency exacerbates pathology in acute experimental ulcerative colitis.

Isabel A Jimenez, Allison P Stilin, Kanako Morohaku, Mahmoud H Hussein, Prasanthi P Koganti, Vimal Selvaraj

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Role of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Isabel A JimenezDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
Allison P StilinDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
Kanako MorohakuDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
Mahmoud H HusseinDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
Prasanthi P KogantiDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
Vimal SelvarajDepartment of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, United States.
Cornell University · USNew York State College of Agriculture & Life Sciences · USJohns Hopkins University · US

Funding

Mechanism of cholesterol regulation by the mitochondrial translocator protein (TSPO)R01DK110059 · NIDDK · CORNELL UNIVERSITY · PI SELVARAJ, VIMAL · 2017 to 2021
$1.6M
NIDDK NIH HHS R01 DK110059
6 · The paper itself

Abstract

In human patients and animal models of ulcerative colitis (UC), upregulation of the mitochondrial translocator protein (TSPO) in the colon is consistent with inflammation. Although the molecular function for TSPO remains unclear, it has been investigated as a therapeutic target for ameliorating UC pathology. In this study, we examined the susceptibility of

Indexed as

coloninflammationintestinal epitheliummast cellmitochondria

Identifiers

PMID36060674
PMCPMC9437295
OpenAlexW4292493938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.