Evidence map›Paper›PMID 36060461›Full record

ArticleHeliyon2022

Comparative performance data for multiplex SARS-CoV-2 serological assays from a large panel of dried blood spot specimens.

François Cholette, Rissa Fabia, Angela Harris, Hannah Ellis, Karla Cachero, Lukas Schroeder, Christine Mesa, Philip Lacap, Corey Arnold, Yannick Galipeau and 13 more

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Autoantibodies targeting angiotensin-converting enzyme 2 are prevalent and not induced by SARS-CoV-2 infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Article
  5. Canada's approach to SARS-CoV-2 sero-surveillance: Lessons learned for routine surveillance and future pandemics.Canadian journal of public health = Revue canadienne de sante publique · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

François CholetteNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Rissa FabiaNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Angela HarrisNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Hannah EllisNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Karla CacheroNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Lukas SchroederNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Christine MesaNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Philip LacapNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Corey ArnoldDepartment of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Canada.
Yannick GalipeauDepartment of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Canada.
Marc-André LangloisDepartment of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Canada.
Karen ColwillLunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health, Toronto, Canada.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health, Toronto, Canada.
Allison McGeerLunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Sinai Health, Toronto, Canada.
Elizabeth GilesNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Jacqueline DayNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Carla OsiowyNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Yves DurocherMammalian Cell Expression, Human Health Therapeutics Research Centre, National Research Council Canada, Montréal, Canada.
Catherine HankinsDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, Canada.
Bruce MazerDepartment of Pediatrics, McGill University, Montréal, Canada.
Michael DrebotNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
John KimNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
COVID-19 Immunity Task Force (CITF) working group
Public Health Agency of Canada · CAMount Sinai Hospital · CAUniversity of Ottawa · CAMcGill University · CANational Research Council Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extent of the COVID-19 pandemic will be better understood through serosurveys and SARS-CoV-2 antibody testing. Dried blood spot (DBS) samples will play a central role in large scale serosurveillance by simplifying biological specimen collection and transportation, especially in Canada. Direct comparative performance data on multiplex SARS-CoV-2 assays resulting from identical DBS samples are currently lacking. In our study, we aimed to provide performance data for the BioPlex 2200 SARS-CoV-2 IgG (Bio-Rad), V-PLEX SARS-CoV-2 Panel 2 IgG (MSD), and Elecsys Anti-SARS-CoV-2 (Roche) commercial assays, as well as for two highly scalable in-house assays (University of Ottawa and Mount Sinai Hospital protocols) to assess their suitability for DBS-based SARS-CoV-2 DBS serosurveillance. These assays were evaluated against identical panels of DBS samples collected from convalescent COVID-19 patients (

Indexed as

Covid-19Dried blood spotsImmunoassaysSARS-CoV-2SerologySerosurveys

Identifiers

PMID36060461
PMCPMC9420314
OpenAlexW4293392998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.