Evidence map›Paper›PMID 36060290›Full record

ArticleInternational journal of cardiology. Cardiovascular risk and prevention2022

Sex-specific performance of the ASCVD pooled cohort equation risk calculator as a correlate of coronary artery calcium in Kampala, Uganda.

Katherine Kentoffio, Matthew S Durstenfeld, Mark J Siedner, Cissy Kityo, Geoffrey Erem, Isaac Ssinabulya, Brian Ghoshhajra, Marcio S Bittencourt, Chris T Longenecker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Cardiovascular risk and prevention, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Hyperglycemia in Pregnancy and Women's Health in the 21st Century.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Katherine KentoffioDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Matthew S DurstenfeldDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Mark J SiednerMassachusetts General Hospital, Center for Global Health, Boston, MA, USA.
Cissy KityoHIV Medicine, Joint Clinical Research Centre, Kampala, Uganda.
Geoffrey EremDepartment of Radiology, St Francis Hospital Nsambya, Kampala, Uganda.
Isaac SsinabulyaDepartments of Radiology and Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Brian GhoshhajraHarvard Medical School, Boston, MA, USA.
Marcio S BittencourtCenter for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Chris T LongeneckerDepartment of Global Health and Division of Cardiology, University of Washington, Seattle, WA, USA.
Harvard University · USUniversity of California, San Francisco · USJoint Clinical Research Centre · UGNsambya Hospital · UGUganda Management Institute · UGUniversidade de São Paulo · BRUniversity of Washington · US

Funding

Epidemiology of coronary artery disease among people with HIV in rural sub-Saharan AfricaR01HL141053 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SIEDNER, MARK J · 2018 to 2021
$3.0M
UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
NHLBI NIH HHS K12 HL143961NHLBI NIH HHS R01 HL141053
6 · The paper itself

Abstract

introductionThe prevalence of cardiovascular disease (CVD) is rising in Sub-Saharan Africa, but it is not known whether current risk assessment tools predict coronary atherosclerosis in the region. Furthermore, sex-specific performance and interaction with HIV serostatus has not been well studied.

methodsThis cross-sectional study compared ASCVD risk scores and detectable coronary artery calcium (CAC>0) by sex in Kampala, Uganda (n = 200). The cohort was enriched for persons living with HIV, and all participants had at least one CVD risk factor. We fit log binomial regression models and constructed ROC curves to assess the correlation between ASCVD scores and CAC>0.

resultsThe mean age was 56. 62% were female and 50% of both men and women were living with HIV. The median 10-year ASCVD risk score was significantly higher in men (11.0%, IQR 7.6-19.4%) than in women (5.1%, IQR 3.2-8.7%), although the prevalence of CAC>0 was similar (8.1 vs 10.5%, p = 0.63). Each 10% increase in ASCVD risk was associated with increased risk of CAC>0 in men (PR 1.59, 95% CI 1.00-2.55, p = 0.05) but not women (PR 1.15, 95% CI 0.44-3.00, p = 0.77). ROC curves demonstrated an AUC of 0.57 for women vs 0.70 for men. Adjustment for HIV serostatus improved the predictive value of ASCVD in women only (AUC 0.78, p = 0.02).

conclusionsASCVD risk score did not correlate with the presence of CAC in women. When HIV status was added to the ASCVD risk score, correlation with CAC was improved in women but not in men.

Indexed as

ASCVD pooled Cohort equations (PCE)Coronary artery calciumCoronary artery diseaseHuman immunodeficiency virus (HIV)SexUganda

Identifiers

PMID36060290
PMCPMC9434411
OpenAlexW4281761343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.