Evidence map›Paper›PMID 36060237›Full record

ArticleInfection and drug resistance2022

Analysis of the Value of Serum Biomarker LBP in the Diagnosis of Spinal Tuberculosis.

Caili Lou, Jian Liu, Zhibo Ren, Jinke Ji, Hongbao Ma, Hui Dong, Linan Wang, Xu Zhang, Ningkui Niu

Abstract read
In one paragraph

Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Wasting phenotype for differentiating spinal tuberculosis from spinal pyogenic infection.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Trends and prospects in spinal tuberculosis research: a future-oriented approach.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caili LouDepartment of Spinal Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Jian LiuClinical Medical School, Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Zhibo RenClinical Medical School, Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Jinke JiClinical Medical School, Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Hongbao MaClinical Medical School, Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Hui DongInstitute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Linan WangClinical Medical School, Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Xu ZhangInstitute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Ningkui NiuDepartment of Spinal Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the correlation between the expression of lipopolysaccharide-binding protein (LBP) in peripheral blood of spinal tuberculosis and clinical diagnosis and to evaluate its value as a diagnostic marker of spinal tuberculosis. Methods: In the experimental group, clinical history data and peripheral blood were collected from 100 patients with spinal tuberculosis who were admitted to the Department of Spine Surgery, General Hospital of Ningxia Medical University from May 2017 to May 2020, and peripheral blood was collected from 30 healthy volunteers in the control group. Screening of differential LBP expression by proteomics and ELISA to verify its expression in peripheral blood of spinal tuberculosis patients. Results: The expression of LBP protein in peripheral blood is significantly higher in patients with spinal tuberculosis than in the normal population; LBP assay values were significantly and positively correlated with CRP and ESR values ( Conclusion: LBP could be a new candidate biomarker for the diagnosis of spinal tuberculosis.

Indexed as

biomarkerLBPproteomicsspinal tuberculosis

Identifiers

PMID36060237
PMCPMC9439074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.