Evidence map›Paper›PMID 36060145›Full record

ArticleBioMed research international2022

The Protective Effect of Sulodexide on Acute Lung Injury Induced by a Murine Model of Obstructive Jaundice.

Penglei Ma, Yue Long, Qiang Fu, Yanhong Liu, Yitian Yang, Weixing Zhao, Qiangwei Liu, Yang Li, Weidong Mi

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Penglei MaAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-6780-1692
Yue LongAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0001-5293-5156
Qiang FuAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.
Yanhong LiuAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.
Yitian YangDepartment of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Weixing ZhaoAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.
Qiangwei LiuAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.
Yang LiAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.
Weidong MiAnesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-3546-0440
Chinese PLA General Hospital · CNHunan Normal University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The effect of sulodexide (SLX) on obstructive jaundice- (OJ-) induced acute lung injury (ALI) in rats was examined in this study. Methods: In this study, 48 rats were randomly assigned to one of six groups: sham, OJ, OJ+saline, OJ+SLX (0.5 mg/ml/d), OJ+SLX (1 mg/ml/d), and OJ+SLX (2 mg/ml/d). The pathological lung injury was assessed by histological analysis and lung injury grading. ELISA kits were used to evaluate the expression of IL-6, IL-1, TNF- Results: The OJ-induced ALI rats showed severe lung injury. The value of IL-6, IL-1 Conclusion: The results suggested that SLX attenuates OJ-induced ALI in rats by protecting the pulmonary microvascular endothelial barrier.

Indexed as

Acute Lung InjuryGlycosaminoglycansJaundice, ObstructiveAnimalsAntioxidantsCadherinsClaudin-5Disease Models, AnimalEvans BlueInterleukin-6RatsTumor Necrosis Factor-alphaAntioxidantsCadherinsClaudin-5Evans Blueglucuronyl glucosamine glycan sulfateGlycosaminoglycansInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID36060145
PMCPMC9439931
OpenAlexW4293795514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.