Evidence map›Paper›PMID 36060029›Full record

ReviewCancer diagnosis & prognosis

Adenoid Cystic Carcinoma (ACC) Infiltrating the Skull Base: A Systematic Review of Clinical Characteristics and Management Strategies.

Othman Bin-Alamer, Ali S Haider, Adhiraj Chaudhary, Kishore Balasubramanian, Tessa Breeding, Paolo Palmisciano, Maryam Haider, Aaron A Cohen-Gadol, Tarek Y El Ahmadieh, Kenny Yu

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Review in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Othman Bin-AlamerCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Ali S HaiderTexas A&M University College of Medicine, Houston, TX, U.S.A.
Adhiraj ChaudharyVardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Kishore BalasubramanianTexas A&M University College of Medicine, Houston, TX, U.S.A.
Tessa BreedingDr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, U.S.A.
Paolo PalmiscianoDepartment of Neurosurgery, Trauma, Gamma Knife Center, Cannizzaro Hospital, Catania, Italy.
Maryam HaiderDepartment of Radiology, Baylor College of Medicine, Houston, TX, U.S.A.
Aaron A Cohen-GadolDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
Tarek Y El AhmadiehDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, U.S.A.
Kenny YuDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, U.S.A.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTo systematically review the patient characteristics and management approaches of adenoid cystic carcinoma (ACC) infiltrating the skull base. MATERIALS AND

methodsAccording to PRISMA guidelines, PubMed, Scopus, and Cochrane were searched to retrieve studies reporting management protocols and survival outcomes of patients with skull base ACCs. Patient characteristics, management strategies, and outcomes were investigated.

resultsThe review encompassed 17 studies involving 171 patients, with a female predominance (57.9%) and a mean age of 49±7.12 years. ACCs mostly infiltrated the paranasal sinus (22.2%), cavernous sinus (8.8%), and nasopharynx (7.1%). Perineural invasion was reported in 6.4% of cases. Facial pain, nasal obstruction, and facial paresthesia were the most common symptoms. Surgical resection (45.6%) was favored over biopsy (12.2%). Employing the free flap technique (4.7%), surgical reconstruction of the bony defect after resection was performed using abdominal and anterior thigh muscle grafts in 1.8% of patients each. As adjuvant management, 22.8% of cases had radiotherapy and 14.6% received chemotherapy. Recurrence of skull base ACCs occurred in 26.9% of cases during a mean follow up-time of 30.8±1.8 months.

conclusionSkull base ACCs pose a surgical challenge mainly due to their proximity to critical neurovascular structures and aggressive behavior. Surgical resection and radiotherapy are shown to be safe and effective treatment modalities. The dismal prognosis and limited data on non-surgical strategies highlight the need for further evaluation of the current management paradigm and upraising innovative therapies to improve patient mortality and quality of life.

Indexed as

Adenoid cystic carcinomareviewskull base

Identifiers

PMID36060029
PMCPMC9425585

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