Evidence map›Paper›PMID 36059998›Full record

ArticleFrontiers in pharmacology2022

Characterization of Nasco grape pomace-loaded nutriosomes and their neuroprotective effects in the MPTP mouse model of Parkinson's disease.

Pathik Parekh, Marcello Serra, Mohamad Allaw, Matteo Perra, Jacopo Marongiu, Giulia Tolle, Annalisa Pinna, Maria Antonietta Casu, Maria Manconi, Pierluigi Caboni and 2 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Recent Trends in Nanoantioxidants.Antioxidants (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pathik ParekhDepartment of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cagliari, Italy.
Marcello SerraDepartment of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cagliari, Italy.
Mohamad AllawDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Matteo PerraDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Jacopo MarongiuDepartment of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cagliari, Italy.
Giulia TolleDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Annalisa PinnaNational Research Council of Italy, Institute of Neuroscience, Cagliari, Italy.
Maria Antonietta CasuCNR Institute of Translational Pharmacology, Cagliari, Italy.
Maria ManconiDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Pierluigi CaboniDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Olivier J J ManzoniINMED, INSERM U1249, Marseille, France.
Micaela MorelliDepartment of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Grape pomaces have recently received great attention for their richness in polyphenols, compounds known to exert anti-inflammatory and antioxidant effects. These pomaces, however, have low brain bioavailability when administered orally due to their extensive degradation in the gastrointestinal tract. To overcome this problem, Nasco pomace extract was incorporated into a novel nanovesicle system called nutriosomes, composed of phospholipids (S75) and water-soluble maltodextrin (Nutriose

Indexed as

antioxidant activitygrape pomace extractnanotechnologyneurodegenerationneuroprotectiontyrosine hydoxylase

Identifiers

PMID36059998
PMCPMC9428270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.