Case report: Directional infusion of peripheral blood stem cells into the necrotic zone in femoral heads through the medial circumflex femoral artery: A tracing study.

Qiang Mao, Weijie Shao, Shuaijie Lv, Peijian Tong, Bangjian He

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In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Qiang MaoDepartment of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Weijie ShaoThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

Shuaijie LvDepartment of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Peijian TongDepartment of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Bangjian HeDepartment of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to explore whether peripheral blood stem cells (PBSCs) infused through the medial circumflex femoral artery to treat osteonecrosis of the femoral head (ONFH) could migrate into the necrotic area of femoral head. Methods: We collected PBSCs from a patient who had bilateral ONFH by apheresis technique using COBE spectra apheresis system (COBE BCT Inc, Lakewood, CO, USA) after subcutaneous injections of granulocyte-colony stimulating factor (G-CSF) at a dosage of 10 μg/kg for 4 days to mobilize PBSCs. After that, 100 MBq 2-[ Results: The total number of monouclear cells in the peripheral blood stem cell suspension was 1.95 × 10 Conclusions: PBSCs could enter into the femoral head and migrate into the necrotic field of femoral head participating in the repair of osteonecrosis after infusion through the medial circumflex femoral artery.

Indexed as

18F-FDGcell trackingmedial circumflex femoral arteryosteonecrosis of the femoral headperipheral blood stem cells

Identifiers

PMID36059815

DOI10.3389/fmed.2022.945268

PMCPMC9433798

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