Evidence map›Paper›PMID 36059632›Full record

ReviewFrontiers in oncology2022

Role of PSMA PET-guided metastases-directed therapy in oligometastatic recurrent prostate cancer.

Matthew Alberto, Arthur Yim, Nathan Papa, Shankar Siva, Joseph Ischia, Karim Touijer, James A Eastham, Damien Bolton, Marlon Perera

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Nuclear medicine in the operating room: present and future.The British journal of radiology · 2026
    Review
  3. Review
  4. International journal of clinical oncology · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Matthew AlbertoDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, VIC, Australia.
Arthur YimDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, VIC, Australia.
Nathan PapaDepartment of Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Shankar SivaDepartment of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Joseph IschiaDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, VIC, Australia.
Karim TouijerUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
James A EasthamUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Damien BoltonDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, VIC, Australia.
Marlon PereraDepartment of Surgery, Austin Health, University of Melbourne, Melbourne, VIC, Australia.
University of Melbourne · AUAustin Health · AUMemorial Sloan Kettering Cancer Center · USMonash University · AUPeter MacCallum Cancer Centre · AU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Oligometastatic prostate cancer (OMPC) has been proposed as an intermediary state between localised disease and widespread metastases, with varying definitions including 1, 3, or ≤5 visceral or bone metastasis. Traditional definitions of OMPC are based on staging with conventional imaging, such as computerised tomography (CT) and whole-body bone scan (WBBS). Novel imaging modalities such as prostate-specific membrane antigen positron emission tomography (PSMA PET) have improved diagnostic utility in detecting early metastatic prostate cancer (PC) metastases compared with conventional imaging. Specifically, meta-analytical data suggest that PSMA PET is sensitive in detecting oligometastatic disease in patients with biochemical recurrence (BCR) post-radical treatment of PC. Recent trials have evaluated PSMA PET-guided metastases-directed therapy (MDT) in oligometastatic recurrent disease, typically with salvage surgery or radiotherapy (RT). To date, these preliminary studies demonstrate promising results, potentially delaying the need for systemic therapy. We aim to report a comprehensive, multidisciplinary review of PSMA-guided MDT in OMPC. In this review, we highlight the utility of PMSA PET in biochemically recurrent disease and impact of PSMA PET on the definition of oligometastatic disease and outline data pertaining to PSMA-guided MDT.

Indexed as

metastastases directed therapymetastatic diseaseoligometastaticprostate cancerPSMA PET

Identifiers

PMID36059632
PMCPMC9433573
OpenAlexW4292411369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.