Evidence map›Paper›PMID 36059430›Full record

ArticleAddiction neuroscience2022

Lateral habenula-projecting central amygdala circuits expressing GABA and NPY Y1 receptor modulate binge-like ethanol intake in mice.

Michel A Companion, David A Gonzalez, Stacey L Robinson, Melissa A Herman, Todd E Thiele

Open access · goldAbstract read
In one paragraph

Article in Addiction neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michel A CompanionDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, CB#3270, Chapel Hill, NC 27599-3270, United States.
David A GonzalezDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, CB#3270, Chapel Hill, NC 27599-3270, United States.
Stacey L RobinsonDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, CB#3270, Chapel Hill, NC 27599-3270, United States.
Melissa A HermanDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, CB#3270, Chapel Hill, NC 27599-3270, United States.
Todd E ThieleDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, CB#3270, Chapel Hill, NC 27599-3270, United States.
University of North Carolina at Chapel Hill · US

Funding

Training on Research in Drug AbuseT32DA007244 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Regina M Carelli · 1990 to 2026
$7.6M
Neuropeptide Y: Role in Ethanol Intake and SensitivityR01AA013573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THIELE, TODD ERIC · 2001 to 2018
$3.8M
The role of corticotropin releasing factor in binge-like ethanol drinkingR01AA022048 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash, TODD Eric THIELE · 2013 to 2026
$3.2M
The role of brainstem norepinephrine in binge alcohol drinking and taste aversionR01AA025809 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TODD Eric THIELE, Montserrat Navarro Thiele · 2018 to 2026
$3.1M
Neuropeptide Y: Role in Ethanol Intake and SensitivityR37AA013573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TODD Eric THIELE · 2019 to 2026
$3.0M
The role of a nucleus tractus solitarius-central amygdala circuit in alcohol-induced plasticity and drinking behaviorR01AA026858 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HERMAN, MELISSA A · 2019 to 2023
$1.7M
Habenula-projecting NPY1R-expressing circuit modulation of binge ethanol intakeF31AA027134 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COMPANION, MICHEL ANTHONY · 2019 to 2020
$74k
NIAAA NIH HHS F31 AA027134NIAAA NIH HHS R01 AA013573NIAAA NIH HHS R01 AA022048NIAAA NIH HHS R01 AA025809NIAAA NIH HHS R01 AA026858NIAAA NIH HHS R37 AA013573NIDA NIH HHS T32 DA007244
6 · The paper itself

Abstract

The central nucleus of the amygdala (CeA) is a critical brain region in the integration of emotional behaviors and is one of the major output areas of the amygdaloid complex. The CeA is composed of GABAergic interneurons and projection neurons which co-express a range of peptides including neuropeptide Y (NPY). Importantly, GABA and NPY signaling, via the NPY Y1 receptor (Y1R), in the CeA modulate binge-like ethanol intake in rodents and these systems undergo neuroplastic alterations following a history of ethanol consumption. Here we assessed the roles of GABAergic and Y1R+ circuits arising from the CeA and innervating the lateral habenula (LHb), a brain region that modulates the aversive properties of ethanol, in modulating binge-like ethanol intake in mice using "drinking in the dark" (DID) procedures. Using an anterograde cre-inducible reporter virus we established the CeA → LHb circuit in male and female vgat-

Indexed as

Binge-like ethanol drinkingCentral amygdalaEthanolGABALateral habenulaNPYY1 receptor

Identifiers

PMID36059430
PMCPMC9435303
OpenAlexW4225150451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.