SynthesisEpidemiology and psychiatric sciences2022
Association of antipsychotic use with breast cancer: a systematic review and meta-analysis of observational studies with over 2 million individuals.
Synthesis in Epidemiology and psychiatric sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Antipsychotic therapy and breast cancer risk: a comprehensive systematic review and meta-analysis.Breast cancer (Tokyo, Japan) · 2026Pooled it
- Mendelian Randomization Studies of Major Depressive Disorder, Schizophrenia, Bipolar Disorder, and Cancers: A PRISMA Review and Meta-Analysis.Endocrine, metabolic & immune disorders drug targets · 2026Pooled it
- Pooled it
- The incidence risk of gynecological cancer by antipsychotic use: a meta-analysis of 50,402 patients.BMC cancer · 2024Pooled it
- Association of antipsychotic use with breast cancer: a systematic review and meta-analysis of observational studies with over 2 million individuals-CORRIGENDUM.Epidemiology and psychiatric sciences · 2022Pooled it
- Antipsychotic exposure is an independent risk factor for breast cancer: A systematic review of epidemiological evidence.Frontiers in oncology · 2022Pooled it
- Antidepressant and Antipsychotic Drug Use and Cancer Risk: Protocol for an Overview of Systematic Reviews and Meta-Analyses.JMIR research protocols · 2025Article
- Wearable Signals for Diagnosing Attention-Deficit/Hyperactivity Disorder in Adolescents: A Feasibility Study.JAACAP open · 2025Article
- Antipsychotics use increases the risk of breast cancer in Women: Findings from systematic review and meta-analysis of observational studies.Comprehensive psychoneuroendocrinology · 2025Review
- Antipsychotic-induced hyperprolactinemia: Toxicologic mechanism and the increased breast cancer risk.Toxicology reports · 2025Review
- Antipsychotic Use and Risk of Breast Cancer in Women With Severe Mental Illness: Replication of a Nationwide Nested Case-Control Database Study.Schizophrenia bulletin · 2024Article
- Mortality in Schizophrenia-Spectrum Disorders: Recent Advances in Understanding and Management.Healthcare (Basel, Switzerland) · 2022Article
- BREAST CANCER AND PROLACTIN: A LIFETIME RELATIONSHIP.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDespite reports of an elevated risk of breast cancer associated with antipsychotic use in women, existing evidence remains inconclusive. We aimed to examine existing observational data in the literature and determine this hypothesised association.
methodsWe searched Embase, PubMed and Web of Science™ databases on 27 January 2022 for articles reporting relevant cohort or case-control studies published since inception, supplemented with hand searches of the reference lists of the included articles. Quality of studies was assessed using the Newcastle-Ottawa Scale. We generated the pooled odds ratio (OR) and pooled hazard ratio (HR) using a random-effects model to quantify the association. This study was registered with PROSPERO (CRD42022307913).
resultsNine observational studies, including five cohort and four case-control studies, were eventually included for review (
conclusionsAntipsychotic use is moderately associated with breast cancer, possibly mediated by prolactin-elevating properties of certain medications. This risk should be weighed against the potential treatment effects for a balanced prescription decision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.