Evidence map›Paper›PMID 36059087›Full record

ArticleJPEN. Journal of parenteral and enteral nutrition2023

Infusion timing and sleep habits of adults receiving home parenteral and enteral nutrition: A patient-oriented survey study.

Hassan S Dashti, Jordan J Rhyner, Kris M Mogensen, Meghna Godbole, Richa Saxena, Charlene Compher, Marion F Winkler

Abstract read
In one paragraph

Article in JPEN. Journal of parenteral and enteral nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. From Ancient Enemas to Tube Feeding, II: Clinical Outcomes and Future Directions Surrounding Commercial Versus Food-Based Formulas in Critical Illness.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2025
    Review
  5. Review
  6. Sleep and home parenteral nutrition in adults: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Comparison between self-reported and actigraphy-derived sleep measures in patients receiving home parenteral nutrition: Secondary analysis of observational data.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hassan S DashtiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1650-679X
Jordan J RhynerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Kris M MogensenDepartment of Nutrition, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-9510-3018
Meghna GodboleCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Charlene CompherBiobehavioral Health Sciences Department, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8117-5387
Marion F WinklerDepartment of Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID 0000-0003-0946-8294

Funding

Genetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0M
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2M
The impact of overnight nutrition support on sleep and circadian rhythm disruption in the ICUK99HL153795 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DASHTI, HASSAN S. · 2021 to 2022
$330k
NHLBI NIH HHS K99 HL153795NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859
6 · The paper itself

Abstract

backgroundThe emerging field of chrononutrition investigates the effects of the timing of nutritional intake on human physiology and disease pathology. It remains largely unknown when patients receiving home nutrition support routinely administer home parenteral nutrition (HPN) and/or home enteral nutrition (HEN).

methodsThe present descriptive study included data collected from a patient-oriented survey designed to assess the timing of infusions and sleep habits of patients receiving HPN and HEN in the United States.

resultsA total of 100 patients were included. Patients had a mean age of 44.1 years and 81% were female. Among 73 patients supported with HPN and 27 patients supported with HEN, 86% and 44% reported overnight infusions, respectively. The median start and end times of overnight infusions were 2100 (interquartile range [IQR] = 1900-2200) and 0800 (IQR = 0700-1000), respectively, for HPN and 2000 (IQR = 1845-2137) and 0845 (IQR = 0723-1000), respectively, for HEN. Overnight infusions started 2.0 h (IQR = 1.1-3.0) and 2.0 h (IQR = 0.6-3.3) before bedtime for HPN and HEN, respectively, and stopped 12.9 min (IQR = -21.3 to 29.1) and 30.0 min (IQR = -17.1 to 79.3) after wake time for HPN and HEN, respectively. Sleep disruption because of nutrition support or urination was most common among patients receiving infusions overnight compared with those receiving infusions continuously or during the daytime.

conclusionsOur survey study focusing on a novel and medically relevant dimension of nutrition found that most HPN-dependent and HEN-dependent patients receive infusions overnight while asleep. Our findings suggest that overnight infusions coinciding with sleep may result in sleep and circadian disruption.

Indexed as

Enteral NutritionParenteral Nutrition, HomeAdultFemaleHumansMaleNutritional SupportSleepSurveys and Questionnaireschrononutritioncircadian rhythmhome enteral nutritionhome parenteral nutritioninfusion timequality of lifesleep disruption

Identifiers

PMID36059087
PMCPMC9839557

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.