ArticleAnalytical and bioanalytical chemistry2022
Mass spectrometry-based metabolomic signatures of coral bleaching under thermal stress.
Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Chilling Injury to Algal Symbionts Induces Host Starvation and Metabolic Reorganization in a Temperate Cnidarian.Molecular ecology · 2026Article
- Coral metabolomic diversity is associated with restoration success.Scientific reports · 2026Article
- Chronic changes in acute zonal occult outer retinopathy mimicking non-progressive retinitis pigmentosa: clinical and laboratory characteristics.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Transcriptional responses of reef-building coral Leptoria phrygia to localized thermal anomalies: a seasonal and experimental approach.Scientific reports · 2026Article
- UPLC-qToF-MS/MS analysis and anti-inflammatory activities of the soft coralRSC advances · 2026Article
- Distinct Host-Specific Bacterial Assemblages in Four CongenericMicroorganisms · 2025Article
- Article
- Multi-omics analysis of the correlation between surface microbiome and metabolome in Saccharina latissima (Laminariales, Phaeophyceae).FEMS microbiology ecology · 2025Article
- The effects of seawater temperature-induced coral bleaching on the aragonite structure and material properties of massiveCoral reefs (Online) · 2025Article
- Metabolomic profiles of stony coral species from the Dry Tortugas National Park display inter- and intraspecies variation.mSystems · 2024Article
- Saving coral reefs: significance and biotechnological approaches for coral conservation.Advanced biotechnology · 2024Review
- Gene expression response under thermal stress in two Hawaiian corals is dominated by ploidy and genotype.Ecology and evolution · 2024Article
- Unlocking the genomic potential of Red Sea coral probiotics.Scientific reports · 2024Article
- Single-polyp metabolomics for coral health assessment.Scientific reports · 2024Article
- Impact of Marine Chemical Ecology Research on the Discovery and Development of New Pharmaceuticals.Marine drugs · 2023Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Coral bleaching caused by climate change has resulted in large-scale coral reef decline worldwide. However, the knowledge of physiological response mechanisms of scleractinian corals under high-temperature stress is still challenging. Here, untargeted mass spectrometry-based metabolomics combining with Global Natural Product Social Molecular Networking (GNPS) was utilized to investigate the physiological response of the coral species Pavona decussata under thermal stress. A wide variety of metabolites (including lipids, fatty acids, amino acids, peptides, osmolytes) were identified as the potential biomarkers and subjected to metabolic pathway enrichment analysis. We discovered that, in the thermal-stressed P. decussata coral holobiont, (1) numerous metabolites in classes of lipids and amino acids significantly decreased, indicating an enhanced lipid hydrolysis and aminolysis that contributed to up-regulation in gluconeogenesis to meet energy demand for basic survival; (2) pantothenate and panthenol, two essential intermediates in tricarboxylic acid (TCA) cycle, were up-regulated, implying enhanced efficiency in energy production; (3) small peptides (e.g., Glu-Leu and Glu-Glu-Glu-Glu) and lyso-platelet-activating factor (lysoPAF) possibly implicated a strengthened coral immune response; (4) the down-regulation of betaine and trimethylamine N-oxide (TMAO), known as osmolyte compounds for maintaining holobiont homeostasis, might be the result of disruption of coral holobiont.
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Registered trials
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