Evidence map›Paper›PMID 36058984›Full record

ArticleBulletin of experimental biology and medicine2022

Transcriptomic Analysis of DNA Repair Pathways in Human Non-Small Cell Lung Cancer Cells Surviving Multifraction X-Ray Irradiation.

M V Pustovalova, A A Guryanova, M I Sorokin, M V Suntsova, A A Buzdin, L Alhaddad, A N Osipov, S V Leonov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

M V PustovalovaMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia. mvpustovalova@gmail.com.
A A GuryanovaMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia.
M I SorokinMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia.
M V SuntsovaI. M. Se-chenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
A A BuzdinMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia.
L AlhaddadMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia.
A N OsipovMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia.
S V LeonovMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia.
Moscow Aviation Institute · RUMoscow Power Engineering Institute · RUSechenov University · RUFederal Medical-Biological Agency · RUMoscow Institute of Physics and Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radioresistant sublines of non-small cell lung cancer cells differing in the p53 status were obtained: A549 (p53 wild type) and H1299 (p53 deficient). The exposure to ionizing radiation was carried out using a standard protocol developed on the basis of empirical clinical experience and consisting in exposure in a dose of 2 Gy once a day, 5 days a week up to total dose of 60 Gy. The cells survived after irradiation demonstrated reduced radiosensitivity, as well as changes in differential gene expression in comparison with parental cells. Some differences in the signaling pathways involved in DNA repair were revealed.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsCell Line, TumorDNA RepairGene Expression Regulation, NeoplasticHumansRadiation ToleranceTranscriptomeTumor Suppressor Protein p53X-RaysTumor Suppressor Protein p53DNA repairionizing radiationnon-small cell lung cancerradioresistancetranscriptomics

Identifiers

PMID36058984
OpenAlexW4294658501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.