Evidence map›Paper›PMID 36058971›Full record

ArticleBulletin of experimental biology and medicine2022

A Method to Determine Xenobiotic Acetylation Rate by Taq SNP rs1495741.

O B Ogarkov, N P Peretolchina, S I Malov, E A Orlova, L A Stepanenko, P A Khromova, I V Malov, S I Kolesnikov

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

O B OgarkovScientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
N P PeretolchinaIrkutsk State Medical University, Irkutsk, Russia. nadine1lenz@gmail.com.
S I MalovIrkutsk State Medical University, Irkutsk, Russia.
E A OrlovaScientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
L A StepanenkoIrkutsk State Medical University, Irkutsk, Russia.
P A KhromovaScientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
I V MalovIrkutsk State Medical University, Irkutsk, Russia.
S I KolesnikovScientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug acetylation plays an important role in the medical practice. Modern methods of acetylation phenotype prediction are based on genotyping of polymorphisms in the second exon of the gene NAT2. Some disadvantages of these methods limit their application in the clinical practice. We developed a method of human genotyping based on identification of NAT2 gene polymorphism rs1495741 by real-time PCR. This method of genotype determination has a number of advantages: high sensitivity, simplicity, possibility of automated interpretation of the results, and feasibility in clinical laboratories.

Indexed as

Arylamine N-AcetyltransferaseAcetylationGenotypeHumansPhenotypePolymorphism, Single NucleotideXenobioticsArylamine N-AcetyltransferaseNAT2 protein, humanXenobioticsacetylationNAT2PCRpolymorphismSNP

Identifiers

PMID36058971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.