Evidence map›Paper›PMID 36058969›Full record

ArticleBulletin of experimental biology and medicine2022

Effect of Photodynamic Therapy on the microRNA Level in Breast Cancer Tissues of Female Wistar Rats.

O V Kazakov, A V Kabakov, A F Poveshchenko, V V Kononchuk, D N Strunkin, L F Gulyaeva, V I Konenkov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

O V KazakovResearch Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. kazakoff_oleg@mail.ru.
A V KabakovResearch Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
A F PoveshchenkoResearch Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
V V KononchukResearch Institute of Molecular Biology and Biophysics - Structural Subdivision of the Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
D N StrunkinResearch Institute of Molecular Biology and Biophysics - Structural Subdivision of the Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
L F GulyaevaResearch Institute of Molecular Biology and Biophysics - Structural Subdivision of the Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
V I KonenkovResearch Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Institute of Cytology and Genetics · RUInstitute of Molecular Biology and Biophysics · RUFederal Research Center of Fundamental and Translational Medicine · RUInstitute of Clinical and Experimental Lymphology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of microRNA (miR-21, miR-221, miR-27a, and miR-429) was studied normal and tumor breast tissues of female Wistar rats before and after photodynamic therapy. In breast cancer, the levels of oncogenic microRNA (miR-21, miR-221, and miR-27a) were increased, while the level of tumor-suppressing miR-429 was reduced in comparison with the intact group. After photodynamic therapy, suppression of the expression levels of oncogenic microRNAs (miR-21, miR-221, and miR-27a) was noted. The level of tumor-suppressing miR-429 in breast tumor tissues remained reduced, as in the untreated breast cancer group.

Indexed as

MicroRNAsNeoplasmsPhotochemotherapyAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticRatsRats, WistarMicroRNAsmirn21 microRNA, ratbreast cancermicroRNAphotodynamic therapy

Identifiers

PMID36058969
OpenAlexW4294659435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.