Evidence map›Paper›PMID 36058966›Full record

ArticleBulletin of experimental biology and medicine2022

Dose-Dependent Effects of Intravenous Mesenchymal Stem Cell Transplantation in Rats with Acute Focal Cerebral Ischemia.

E A Cherkashova, D D Namestnikova, I L Gubskiy, V A Revkova, K K Sukhinich, P A Mel'nikov, V P Chekhonin, L V Gubsky, K N Yarygin

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

E A CherkashovaFederal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia.
D D NamestnikovaFederal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia. dadnam89@gmail.com.
I L GubskiyFederal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia.
V A RevkovaFederal Research Clinical Center of Specialized Types of Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, Moscow, Russia.
K K SukhinichN. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
P A Mel'nikovV. P. Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
V P ChekhoninPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
L V GubskyFederal Center of Brain Research and Neurotechnologies, Federal Medical-Biological Agency of Russia, Moscow, Russia.
K N YaryginV. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
Ministry of Health of the Russian Federation · RUFederal Medical-Biological Agency · RUKoltzov Institute of Developmental Biology · RUPirogov Russian National Research Medical University · RURussian Medical Academy of Continuous Professional Education · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous transplantation of mesenchymal stem (stromal) cells (MSC) is a promising approach to the treatment of ischemic stroke. In the published reports of the already completed preclinical and clinical studies the dosages of transplanted MSC greatly vary. However, the optimal dosage has not been determined. The dose-dependent effect of intravenous MSC transplantation was studied, in rats with experimental cerebral infarction. To this end, 5×10

Indexed as

Brain IschemiaMesenchymal Stem Cell TransplantationStrokeAnimalsDisease Models, AnimalInfarction, Middle Cerebral ArteryRatscell therapyintravenous administrationischemic strokemesenchymal stem cellsmodel of middle cerebral artery occlusion

Identifiers

PMID36058966
OpenAlexW4294658687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.