Evidence map›Paper›PMID 36058964›Full record

ArticleBulletin of experimental biology and medicine2022

Effect of Conditioned Media of Limbal Epithelial Cells and Corneal Stromal Cells on Functional Activity of Limb Mesenchymal Stem Cells.

N A Bondarenko, M A Surovtseva, I I Kim, A P Lykov, I A Iskakov, A N Trunov, V V Chernykh, O V Poveshchenko

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

N A BondarenkoResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. bond802888@yandex.ru.
M A SurovtsevaResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
I I KimResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
A P LykovResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
I A IskakovS. N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health - Novosibirsk Branch, Novosibirsk, Russia.
A N TrunovS. N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health - Novosibirsk Branch, Novosibirsk, Russia.
V V ChernykhS. N. Fyodorov Eye Microsurgery Federal State Institution of the Russian Ministry of Health - Novosibirsk Branch, Novosibirsk, Russia.
O V PoveshchenkoResearch Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Intersectoral Research and Technology Complex Eye Microsurgery · RUInstitute of Clinical and Experimental Lymphology · RUInstitute of Cytology and Genetics · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effect of conditioned media from limbal epithelial stem cells, fibroblasts, and corneal keratocytes on the functional activity of human limbal mesenchymal stem cells. It was shown that the conditioned media from limbal epithelial stem cells reduced proliferative activity and inhibited migration of limbal mesenchymal stem cells. In the conditioned media of limbal epithelial stem cells, increased concentrations of VEGF and TNFα and reduced concentration of BDNF, vimentin, and fibronectin were found. The conditioned medium from corneal stromal cells did not affect functional activity of mesenchymal stem cells in the limbus. These data contribute to the understanding of the interaction of cells in the limbal niche and with corneal cells essential for the maintenance of the cellular homeostasis in the cornea.

Indexed as

Epithelium, CornealLimbus CorneaeMesenchymal Stem CellsBrain-Derived Neurotrophic FactorCell DifferentiationCorneaCulture Media, ConditionedEpithelial CellsFibronectinsHumansStromal CellsTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AVimentinBrain-Derived Neurotrophic FactorCulture Media, ConditionedFibronectinsTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AVimentinconditioned mediacorneal fibroblastskeratocyteslimbal epithelial stem cellsmesenchymal stem cells

Identifiers

PMID36058964
OpenAlexW4294658471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.